Chih-Kuang Wang

 Professor Chih-Kuang Wang, Ph.D.

 王志光　

 　 　

Lab:Nano-Bio Chemistry Laboratory (N836)

Tel: 886-7-3121101 ext. 2677

Fax: 886-7-3125339

E-mail:ckwang@kmu.edu.tw

Lab website: http://nbiomaterial.dlearn.kmu.edu.tw/lab.htm

Education and Experience:

         M.S. Department of Materials Science and Engineering, National Cheng Kung University, (1990-1992)

          Ph.D., Department of Materials Science and Engineering, National Cheng Kung University , (1992-1998)

          Postdoctoral fellow, Material Research Laboratories (MRL), 2003, Industrial Technology Research Institute – (ITRI), (1998-2003)

          Assistant professor, Department of Medical and Applied Chemistry, Kaohsiung Medical University, (2003-2009)

          Associate professor, Department of Medical and Applied Chemistry, Kaohsiung Medical University, (2009- 2015)

          Professor, Department of Medical and Applied Chemistry, Kaohsiung Medical University, (2015- present)

 　

Research Interests:

  • Design and fabrication of scaffold materials for tissue engineering of bone & cartilage

  • Polymeric micelle micro-, nano-particle system for drug/gene delivery

  • Other interesting at advanced materials ….

　

 

Selected Publications:

1.    Yin-Chih Fu, Tzu-Fun Fu,Hung-Jen Wang, Che-Wei Lin, Shun-Cheng Wu, Gang-Hui Lee,Chih-Kuang Wang*, Aspartic acid based modified PLGA-PEG nanoparticles for bone targeting: in vitro and in vivo evaluations, have accepted in Acta Biomaterialia at July 15 of 2014. (IF:5.093 at 2012, ranking:3/79=3.8%; inENGINEERING, BIOMEDICAL)

2.    Chau-Zen Wang, Yin-Chih Fu, Yan-Hsung Wang, Po-Len Liu, Shih-Ciang Jian, Mei-Ling Ho, Chih-Kuang Wang*, Synthesis and characterization of cationic polymeric nanoparticles as simvastatin carriers for enhancing the osteogenesis of bonemarrowmesenchymal stemcells, have accepted in Journal of Colloid and Interface Science at June 16 of 2014. (IF: 3.172 at 2012, ranking:44/135=32.6%; inCHEMISTRY, PHYSICAL)

3.    Zheng-Wei Liu, Hung-Chia Chou, Szu-Hsien Chen, Ching-Ting Tsao, Ching-Nan Chuang, Li-Chiun Cheng, Chen-Han Yang, Chih-Kuang Wang* and Kuo Huang Hsieh*, Mechanical and thermal properties of thermoplastic polyurethane-toughened polylactide-based nanocomposites, Polymer Composites, Online Version at Dec. 26, 2013. (IF:1.482 at 2012, ranking:6/24=25.0%; inMATERIALS SCIENCE, COMPOSITE)

4.    Yan-Hsung Wang,Yin-Chih Fu, Hui-Chi Chiu, Chau-Zen Wang, Shao-Ping Lo,Mei-Lin Ho, Po-Len Liu, Chih-Kuang Wang*, Cationic nanoparticles with quaternary ammonium functionalized PLGA-PEG-based copolymers for potent gene transfection,Journal of Nanoparticle Research, 15:2077-2092. 2013. (IF:2.175 at 2012, ranking:57/241=23.6%; inMATERIALS SCIENCE, MULTIDISCIPLINARY)

5.    I-Chun Tai, Yin-Chih Fu, Chih-Kuang Wang,Je-Ken Chang, Mei-Ling Ho*, Local delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repair, International Journal of Nanomedicine,8:3895-3905, 2013.(IF:3.463 at 2012, ranking:60/260=23.1%; inPHARMACOLOGY & PHARMACY)

6.    Yin-Chih Fu,Chung-Hwan Chen, Chau-ZenWang, Yan-Hsiung Wang, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho*, Chih-Kuang Wang*, Preparation of porous bioceramics using reverse thermo-responsive hydrogels in combination with rhBMP–2carriers:In VitroandIn Vivoevaluation, Journal of the Mechanical Behavior of Biomedical Materials, 27:64-76, 2013.(IF:2.814 at 2011, ranking:15/72=20.8%; IF:2.368 at 2012, ranking:25/79=31.6% inENGINEERING, BIOMEDICAL)

7.    Chi-Hung Lee, Szu-Hsien Chen, Yen-Zen Wang, Chao-Chien Lin, Chih-Kai Huang, Ching-Nan Chuang, Chih-Kuang Wang*, Kuo-Huang Hsieh*, Preparation and characterization of proton exchange membranes based on semi-interpenetrating sulfonated poly(imide-siloxane)/epoxy polymer networks,Energy 55:905-915, 2013) (IF:3.487 at 2011, ranking:4/52=7.7%; IF:3.651 at 2012, ranking:2/54=3.7% inTHERMODYNAMICS)

8.    Szu-Hsien Chen, Ching-Ting Tsao, Chih-Hao Chang, Yi-Ting Lai, Ming-Fung Wu, Ching-Nan Chuang, Hung-Chia Chou, Chih-Kuang Wang*, Kuo-Haung Hsieh*,Assessment of reinforced poly(ethylene glycol) chitosan hydrogels as dressings in a mouse skin wound defect model, Materials Science and Engineering C –Materials for Biological Applications,33:2584-2594, 2013. (IF: 2.686 at 2011, ranking:10/25=40.0%;IF: 2.404 at 2012, ranking:11/27=40.7% in MATERIALS SCIENCE, BIOMATERIALS)

9.    Szu-Hsien Chen, Ching-Ting Tsao, Hung-Chia Chou, Chih-Hao Chang, Ching-Te Hsu, Ching-Nan Chuang, Chih-Kuang Wang*, Kuo-Huang Hsieh*, Synthesis of poly (lactic acid)-based polyurethanes, Polymer International, 62:1159-1168, 2013. (IF:1.902 at 2011, ranking:25/78=32.1%; IF:2.125 at 2012, ranking:25/83=30.1% inPOLYMER SCIENCE)

10. Szu-Hsien Chen, Ching-Ting Tsao, Chih-Hao Chang, Yi-Ting Lai, Ming-Fung Wu, Zheng-Wei Liu, Ching-Nan Chuang, Hung-Chia Chou, Chih-Kuang Wang*, Kuo-Haung Hsieh*, Synthesis and characterization of reinforced poly(ethylene glycol) chitosan-Hydrogel as wound dressing materials, Macromolecular Materials and Engineering,298:429-438, 2013. (IF:1.986 at 2011, ranking:63/231=27.3%; IF:2.338 at 2012, ranking:52/239=21.7% inMATERIALS SCIENCE, MULTIDISCIPLINARY)

11. Szu-Hsien Chen, Ching-Ting Tsao, Chih-Hao Chang, Yao-Ming Wu, Zheng-Wei Liu, Chun-Pin Lin, Chih-Kuang Wang*, Kuo-Huang Hsieh*, Synthesis and characterization of thermal-responsivechitin-based polyurethane copolymer as a smart material, Carbohydrate Polymers, 88:1483-1487, 2012. (IF: 3.628 at 2011, ranking:4/71=5.63%; IF: 3.479 at 2012, ranking:7/71=9.8% in CHEMISTRY, APPLIED)

12. Chau-Zen Wang, Mei-Ling Ho, Wen-Cheng Chen, Chien-Chih Chiu, Yung-Li Hung, Chih-Kuang Wang*, Shun-Cheng Wu,Characterization and enhancement of chondrogenesis in porous hyaluronic acid-modified scaffolds made of PLGA(75/25) blended with PEI-grafted PLGA(50/50), Materials Science and Engineering C –Materials for Biological Applications, 31:1343-1351, 2011. (IF: 2.686 at 2011, ranking:10/25=40.0%;IF: 2.404 at 2012, ranking:11/27=40.7% in MATERIALS SCIENCE, BIOMATERIALS)

13. Chih-Kuang Wang, Chau-Zen Wang, Jen-Chyan Wang, Chun-Cheng Hung, Wan-Yun Li, Wen-Cheng Chen*, Preparation and characterization of calcium phosphate deposited on gold nanoparticles, Journal of Non-Crystalline Solids,356:927-932, 2010. (IF: 1.537 at 2011, ranking:5/25=20.00%; IF: 1.597 at 2012, ranking:5/26=19.2%  in MATERIALS SCIENCE, CERAMICS)

14. Shun-Cheng Wu, Chung-Hwan Chen, Je-Ken Chang, Yin-Chih Fu, Chih-Kuang Wang, Rajalakshmanan Eswaramoorthy, Yi-Shan Lin, Yao-Hsien Wang, Sung-Yen Lin, Gwo-Jaw Wang, Mei-Ling Ho*, Hyaluronan initiates chondrogenesis mainly via CD44 in human adipose derived stem cells, Journal of Applied Physiology, 114:1610-1618, 2013) (IF:3.753 at 2011, ranking:6/85=7.0%; IF:3.484 at 2012, ranking:7/84=8.3% inSPORT SCIENCES)

15. Chung-Hwan Chen, Yi-Shan Lin, Yin-Chih Fu, Chih-Kuang Wang, Shun-Cheng Wu,Gwo-Jaw Wang, Rajalakshmanan Eswaramoorthy,Yan-Hsiung Wang, Chau-Zen Wang, Yao-Hsien Wang, Sung-Yen Lin, Je-Ken Chang*, Mei-Ling Ho*, Electromagnetic fields enhance chondrogenesis of human adipose-derived stem cells in a chondrogenic microenvironment in vitro. Journal of Applied Physiology, 114:647-655, 2013.(IF:3.753 at 2011, ranking:6/85=7.0%; IF:3.484 at 2012, ranking:7/84=8.3% inSPORT SCIENCES)

16. Pei-Chien Tsai, Chi-Ying Hsieh, Chien-Chih Chiu, Chih-Kuang Wang, Long-Sen Chang, Shinne-Ren Lin*, Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway, Toxicon, 60:734-43. 2012. (IF:2.508 at 2011, ranking:109/261=41.7%; IF:2.924 at 2012, ranking:79/260=30.3% inPHARMACOLOGY & PHARMACY)

17. Po-Len Liu, Jong-Rung Tsai, Chien-Chih Chiu, Jhi-Jhu Hwang, Shah-Hwa Chou, Chih-Kuang Wang, Shu-Jing Wu, Yuh-Lien Chen, Wen-Chi Chen, Yung-Hsiang Chen,* Inn-Wen Chong*, Decreased expression of thrombomodulin is correlated with tumor cell invasiveness and poor prognosis in nonsmall cell lung cancer, Molecular Carcinogenesis, 49:874-881, 2010. (IF:3.164 at 2011, ranking:109/261=41.7%; IF:4.269 at 2012, ranking:48/196=24.4% inONCOLOGY)

18. Chau-Zen Wang, Shih-Mao Chen, Chung-Hwan Chen, Chih-Kuang Wang, Gwo-Jaw Wang,  Je-Ken Chang, Mei-Ling Ho*, The effect of the local delivery of alendronate on human adipose-derived stem cell-based bone regeneration, Biomaterials, 31:8674-8683, 2010. (IF: 7.404 at 2011, ranking:2/72=2.77%; IF: 7.604 at 2012, ranking:3/79=3.9%  in ENGINEERING, BIOMEDICA)

19. Rajalakshmanan Eswaramoorthy, Chih-Kuang Wang, Wen-Cheng Chen, Ming-Jer Tang, Mei-Ling Ho, Chi-Ching Hwang, Hui-Min Wang, Chau-Zen Wang*, DDR1 regulates the stabilization of cell surface E-Cadherin and E-Cadherin-mediated cell aggregation, Journal of Cellular Physiology, 224:387-397 , 2010. (IF: 3.874 at 2011, ranking:12/79=15.18%; IF: 4.218 at 2012, ranking:13/79=16.4% in PHYSIOLOGY)

20. Jen-Chyan Wang, Chia-Ling Ko, Chun-Cheng Hung, Yu-Chang Tyan, Chern-Hsiung Lai, Wen-Cheng Chen*, Chih-Kuang Wang, Deriving fast setting properties of tetracalcium phosphate/dicalcium phosphate anhydrous bone cement with nanocrystallites on the reactant surfaces,Journal of Dentistry, 38:158-165, 2010. (IF:2.947 at 2011, ranking: 6/81 =7.4 %; IF:3.200 at 2012, ranking: 7/82 =8.5 % in DENTISTRY, ORAL SURGERY & MEDICINE)

21. Shun-Cheng Wu, Je-Ken Chang, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho*, Enhancement of chondrogenesis of human adipose derived stem cells in a hyaluronan-enriched microenvironment, Biomaterials, 31:631-640, 2010. (IF: 7.404 at 2011, ranking:2/72=2.77%; IF: 7.604 at 2012, ranking:3/79=3.9%  in ENGINEERING, BIOMEDICA)

22. Yu-Chang Tyan*, Ming-Hui Yang, Shiang-Bin Jong, Chih-Kuang Wang, Jentaie Shiea, Melamine contamination, Analytical and Bioanalytical Chemistry, 395:729–735, 2009. (IF: 3.778 at 2011, ranking:13/73=17.8%; IF: 3.659 at 2012, ranking:9/75=12.0% in Chemistry, analytical)

23. C.C. Chiu*, H.W. Chang, D.W. Chuang, F.R. Chang, Y.C. Chang, Y.S. Cheng, S.S. Lee, C.K. Wang, Jeff Y.F. Chen, Y.C. Liu, Y.C. Wu, Fern plant-derived protoapigenone leads to DNA damage, apoptosis and G2/M, arrest in lung cancer cell line H1299, DNA and Cell Biology, 28:501-506, 2009. (IF:2.072 at 2011 ; ranking:101/157= 64.33% in GENETICS & HEREDITY)

24. Chih-Kuang Wang, Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Chung-Hwan Chen, Yin-Chih Fu*, Hwai-Hui Fu, Controlled-release of rhBMP-2 carriers in the regeneration of osteonecrotic bone, Biomaterials 30: 4178–4186, 2009. (IF: 7.365 at 2009 ; ranking:2/59=3.39% in ENGINEERING, BIOMEDICA) (IF: 7.404 at 2011 ; ranking:2/72=2.77% in ENGINEERING, BIOMEDICA)

25. C.H. Tseng, Y.L. Chen, C.M. Lu, C.K. Wang, Y.T. Tsai, R.W. Lin, C.F. Chen, Y.F. Chang, G.J. Wang, M.L. Ho, and C.C. Tzeng*, Synthesis and Anti-osteoporotic Evaluation of Certain 3-Amino-2-hydroxypropoxyisoflavone Derivatives, European Journal of Medicinal Chemistry 44:3621-3626, 2009. (IF:3.346 at 2011 ; ranking: 13/59=22.03% in Chemistry, Medicinal)

26. J.K. Chang, C.J. Li, H.J. Liao, C.K. Wang, G.J. Wang, M.L. Ho*, “Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators pro-apoptotic factors in cultured human osteoblasts, Toxicology 258:148–156, 2009. (IF:3.681 at 2011 ; ranking: 16/83=19.27% in TOXICOLOGY)

27. H. Nie, M.L. Ho, C.K. Wang, C.H. Wang, Y.C. Fu*,BMP-2 plasmid loaded PLGA/HAp composite scaffolds for treatment of bone defects in nude mice,Biomaterials 30: 892–901, 2009. (IF: 7.604 at 2012, ranking:3/79=3.9%  in ENGINEERING, BIOMEDICA)

28. C.K. Wang, S.H. Chen, W.Y. Li, C.H. LaiandW.C. Chen*, Bioactive glass shell growth of a Si–Na–Ca–P layer on gold nanoparticles functionalized with mercaptopropyltrimethyloxysilane- silicate-tetraethylothosilicate”, Surface Review and Letters 16: 37–42, 2009.(IF:0.493 at 2011 ; ranking:60/69=86.9% in PHYSICS, CONDENSED MATTER)

29. B.H. Chen, K.I. Chen, M.L. Ho, H.N. Chen, W.C. Chen, C.K. Wang*, Synthesis of calcium phosphates and porous hydroxyapatite beads prepared by emulsion method, Materials Chemistry and Physics, 113: 365-371, 2009. (IF: 2.234 at 2011 ; ranking:51/231=22.1% in MATERIALS SCIENCE, MULTIDISCIPLINARY)

30. W.C. Chen, C.C. Hung, Y.C. Huang, C.K. Wangand J.C. Wang*, Fracture load of provisional fixed partial dentureswith long-span fiber-reinforced acrylic resinand thermocycling, Journal of Dental Sciences, 4: 25-31, 2009. (IF: 0.222 at 2011 ; ranking:80/81=98.9% inDENTISTRY, ORAL SURGERY & MEDICINE)

31. Mei-Ling Ho, Yin-Chih Fu, Gwo-Jaw Wang, Hui Ting Chen, Je-Ken Chang, Tsung Hsien Tsai, Chih-Kuang Wang *, Controlled release carrier of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite, Journal of Controlled Release, 128: 142-148, 2008.(IF:7.633 at 2012 ; ranking:15/261=5.7% in PHARMACOLOGY & PHARMACY)

32. Y.C. Fu, H. Nie, M.L. Ho, C.K. Wang, C.H. Wang*, Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2, Biotechnology & Bioengineering, 99: 996-1006, 2008. (IF: 3.946 at 2011 ; ranking:28/157=17.8% in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

33. Y.C. Fu, M.L. Ho, S.C. Wu, H.S. Hsieh, C.K. Wang*, Porous bioceramic bead prepared by calcium phosphate with sodium alginate gel and PE powder, Materials Science and Engineering C, 28: 1149-1158, 2008. (IF: 2.686 at 2011 ; ranking:10/25=40.0% in MATERIALS SCIENCE, BIOMATERIALS)

34. Yi-Pang Lee, Chih-Kuang Wang, Tsui-Hsien Huang, Chun-Cheng Chen, Chia-Tze Kao,Shinn-Jyh Ding*, In Vitro characterization of postheat-treated plasma-sprayed hydroxyapatite coatings, Surface and Coatings Technology, 197: 367–374, 2005. (IF: 1.941 at 2012 ; ranking:3/17=17.64% in MATERIALS SCIENCE, COATINGS & FILMS)

35. Chien-Ping Ju*, Chih-Kuang Wang, Hung-Yih Cheng, Jiin-Huey Chern Lin, Process and Wear Behavior of Monolithic SiC and Short Carbon Fiber-SiC Matrix Composite, Journal of Materials Science, 35: 4477-4484, 2000. (IF: 2.163 at 2012 ; ranking: 58/241=24.06% in MATERIALS SCIENCE, MULTIDISCIPLINARY)

36. Chih-Kuang Wang, Jiin-Huey Chern Lin, Chien-Ping Ju*, Effect of doped bioactive glass on structure and properties of sintered hydroxyapatite, Materials Chemistry and Physics, 53:138-149, 1998.(IF: 2.072 at 2012 ; ranking:61/241=25.3% in MATERIALS SCIENCE, MULTIDISCIPLINARY) (IF: 2.234 at 2011)

37. Chih-Kuang Wang, Jiin-Huey Chern Lin*, Chien-Ping Ju, Hong Choon Ong and Robert P. H. Chang, “Structural characterization of pulsed laser-deposited hydroxyapatite on titanium substrate", Biomaterials, 18:1331-1338, 1997. (IF: 7.604 at 2012, ranking:3/79=3.9%  in ENGINEERING, BIOMEDICA)

International conference papers

1.    Chih-Yun Lee, Jia-Huie Lin, Hui-Chi Chiu, Chih-Kuang Wang*, Detection of Cathepsin-Kactivity for osteoarthritic diagnosis using FRET with a gold nanorod-based fluorescent probe, the 41st Annual Meeting & Exposition of the Controlled Release Society, July 13-16, 2014, in the Hilton Chicago in Chicago, Illinois, USA.

2.    Che-Wei Lin,Yin-Chih Fu, Hung-Jen Wang, Shun-Cheng Wu, Chih-Kuang Wang*, Aspartic Acid BasedPeptides Modifyon PLGA-PEG Nanoparticles for Bone Targeting, the 41st Annual Meeting & Exposition of the Controlled Release Society, July 13-16, 2014, in the Hilton Chicago in Chicago, Illinois, USA.

3.    C.K. Wang* ,Y.C. Fu, T.F. Fu,C.H. Chen, H.J. Wang, M.L. Ho, Oligopeptide of aspartic acid functionalized PLGA-PEG-based copolymers for potent bone targeting nanoparticles, 15th Asian Chemical Congress, Resorts World Sentosa, Singapore, Aug. 19-23, 2013.

4.    C.K. Wang*, Y.C. Fu, T.F. Fu,H.J. Wang, C.Z. Wang, M.L. Ho, Synthesis and Characterization of Aspartic acid Modify PLGA-g-PEG Nanoparticles for Bone Targeting, Annual Meeting of the Orthopaedic Research Society, Henry B. Gonzalez Convention Center, San Antonio, Texas, USA, January 26-29, 2013.

5.    Y.C. Fu, S.C. Chien, C.H. Chen, J.K. Chang, M.L. Ho, C.K. Wang*, Porous bioceramic was fabricated using thermo-responsive hydrogel combined with controlled release of rhBMP-2 carriers for non-union bone defect, Annual Meeting of the Orthopaedic Research Society, Henry B. Gonzalez Convention Center, San Antonio, Texas, USA, January 26-29, 2013.

6.    C.K. Wang*, Y.C. Fu, M.L. Ho,C.Z.Wang, Bioceramic scaffolds combined with controlled release of rhBMP-2 microcarriers for non-union bone healing, 9th World Biomaterials Congress (WBC) Chengdu, China, 1-5 June, 2012.

7.    Y.C. Fu* , C.K. Wang, J.K. Chang, C.H. Chen, G.J. Wang, M.L. Ho, New porous bioceramic material formed via thermo-responsive hydrogel template, 58rd Annual Meeting of the Orthopaedic Research Society, Moscone West Convention Center, San Francisco, California, USA, February 4-7, 2012.

8.    C.K.Wang*, Y.C. Fu, , C.Z. Wang, S.C. Chien, M.L. Ho, Biodegradable bis(PLGA-phe-PEG)-qDETA cationic nanoparticles for local hydrophobic drug delivery, The 38th Annual Meeting & Exposition of the Controlled Release Society, National Harbor, Maryland, U.S.A, Jul 30 – Aug 3, 2011.

9.    C.K. Wang*; Y.C. Fu, S.C. Chien, C.Z. Wang, M.L. Ho, Biphasic calcium phosphate porous scaffold made by thermo-responsive hydrogel, 29th ANNUAL CONFERENCE of the CANADIAN BIOMATERIALS SOCIETY, Vancouver and at the University of British Columbia, Canada on June 1-4, 2011.

10. M.L. Ho, C.Z. Wang, S.M. Chen, C.H. Chen, C.K. Wang, G.J. Wang, J.K. Chang, Local delivery of alendronate enhances human adipose derived stem cell based bone regeneration, 7th Combined Meeting of the Orthopaedic Research Societies, Kyoto, Japan, Oct 16-20, 2010.

11. C.K.Wang*, Y.H. Wang, S.P. Lo, B.H. Chen , and G.J. Wang, Novel cationic nanoparticles of bis(PLGA-PEG)-qDETA copolymers for gene transfection, The 37th Annual Meeting & Exposition of the Controlled Release Society, Portland, Oregon, U.S.A, 10-14, July, 2010.

12. M.L. Ho*, S.C. Wu, C.K. Wang, G.J. Wang, Hyaluronan-enriched microenvironment induces chondrogenic differentiation of human adipose derived stem cells, 55rd Annual Meeting of the Orthopaedic Research Society,Las Vegas, Nevada, USA, February 22 – 25, 2009.

13. Y.C. Fu*, H. Nie, M.L. Ho, C.K. Wang, H. Huang, C.H. Wang, Optimized bone regeneration based on sustained release from 3D scaffold, European Calcified Tissue Society, 24-28 May, Barcelona Spain, 2008.

14. W.C. Chen, S.H. Chen, J.C. Wang, C.C. Hung, W.Y. Li, C.K. Wang*, Calcium phosphate shell on functionalized gold nanoparticles, International Association For Dental Research (IADR) 86th General Session & Exhibition , July 2-5, 2008, Toronto, Canada.

15. S.C. Wu, J.K. Chang, C.K. Wang, I.C. Ting, G.J. Wang, M.L. Ho*, Cytocompatibility of a noval hyaluronic acid modified biodegradable scaffold with human adipose derived stem cells for application of cartilage tissue engineering, 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, California, USA, February 11 – 14, 2007.

16. C.K. Wang*, H.S. Hsieh, Y.J. Guo, Study characterization and drug delivery on porous calcium phosphates beads by novel fabrication, Taiwan-Japan Advanced Biomaterials Symposium, Taipei, Taiwan, ROC, Oct. 4-5, 2004.

17. J.H. Chern Lin*, C.K. Wang, C.P. Ju, “Structural/chemical characterization of pulsed laser-deposited hydroxyapatite film on titanium substrate.", Fifth International Conference on Composites Engineering ICCE/5, Las Vegas, Caesars Palace Hotel, USA, July 1, 1998.

18. C.P. Ju, J.H. Chern Lin*, C.K. Wang, R.P.H. Chang, “Characterization of Pulsed Laser-Deposited Hydroxyapatite on Titanium Substrate.", Third International Congress on Dental Materials, Sheraton Waikiki, Hawaii, USA, November 4-8, 1997.

19. J.H. Chern Lin*, C.K. Wang, C.P. Ju, “Structure and Properties of Bioactive Glass-Doped Hydroxyapatite.", Third International Congress on Dental Materials, Sheraton Waikiki, Hawaii, USA, November 4-8, 1997.

20. Wang, C. K., Cheng, H. Y. , Chern Lin, J. H. and C. P. Ju*, “Process and Wear of Short Carbon Fiber/Silicon Carbide Matrix Composite", IUMRS-ICAM-93 Tokyo, Japan, Aug. 30 – Sep. 5, 1993.

21.

國內會議論文

1.    李之昀, 林佳慧, 王志光*, 全金螢光共振能量轉移新系統模式作為近紅外光對比劑應用在早期骨關節炎診斷, 2014中華民國生物醫學工程創意競賽, 高雄市路竹科學園區, 高雄市, 中華民國, 2014。(佳作獎)

2.    潘力誠, 林宏哲, 王志光*,鄭添祿, Study of bifunctional polymeric nanoparticles with gold nanocluster image probe and anti-PEG tumour-targeted drug delivery, 2014年中華民國生醫材料及藥物制放年會, 103年05月02日,清華大學, 新竹,中華民國, 2014。

3.    王宏仁, 林哲緯, 傅尹志, 傅子芳, 何美泠, 王志光*,Oligopeptide of aspartic acid modify PLGA-PEG nanoparticles for bone targeting in vivo evaluation, 2014年中華民國生醫材料及藥物制放年會, 103年05月02日,清華大學, 新竹,中華民國, 2014。

4.    潘力誠, 林宏哲, 王志光*,鄭添祿, 含影像探針與聚乙二醇抗體標靶之藥物奈米載體合成與性質研究, 2013生物醫學工程科技研討會暨國科會醫學工程學門成果發表會, 102年11月15-16日,清華大學, 新竹,中華民國, 2013。

5.    王宏仁, 林哲緯, 傅尹志, 傅子芳, 何美泠, 王志光*, 天門冬胺酸寡聚胜肽修飾PLGA-PEG高分子作為骨標靶奈米載體在生物體內性質評估, 2013生物醫學工程科技研討會暨國科會醫學工程學門成果發表會, , 102年11月15-16日,清華大學, 新竹,中華民國, 2013。

6.    潘力誠,王志光*,鄭添祿, PEG修飾奈米金桿與具PEG抗體癌細胞之體外辨識與光熱治療研究, 中華民國生醫材料及藥物制放學會 2013 年會暨國科會醫工學門成果發表會, 103年05月4-5日,義守大學, 高雄,中華民國, 2013。

7.    林佳慧,王志光*, 奈米金桿作為螢光共振能量轉移系統之螢光探針應用在早期骨關節炎診斷研究, 中華民國生醫材料及藥物制放學會 2013 年會暨國科會醫工學門成果發表會, 103年05月4-5日,義守大學, 高雄,中華民國, 2013。

8.    王耀賢, 路卡曼, 王志光, 蔡紫琳, 劉瓊月, 張瑞根, 何美泠, PLGA-alendronate enhances bone repair in femoral bone defect in rats, 2013 Annual Meeting of Formosa Association of Regenerative Medicine, Taipei, Taiwan, Mar 2, 2013.

9.    潘力誠¸ 王志光*, 劉伯侖, 鄭添祿, 傅尹志, 具PEG免疫抗體標的的奈米PEG-PLGA基質載體之研究, 中華民國生醫材料及藥物制放學會 2012 年會暨研討會 , 102年04月28日, 台北醫學大學, 台北,中華民國, 2012。

10. 傅尹志, 林佳慧, 王彥雄, 王昭仁, 何美泠, 王志光*, 新式陽離子型兩性生醫高分子(Bis(PLGA-phe-PEG)-qDETA)攜帶親脂性藥物之奈米粒子特性評估, 2012生物醫學工程科技研討會暨國科會醫學工程學門成果發表會, 101年11月17-18日,中原大學, 桃園,中華民國, 2012。

11. 王宏仁, 林哲緯, 傅尹志, 傅子芳, 何美泠, 王志光*, 天門冬胺酸修飾PLGA-g-PEG高分子作為骨標靶奈米載體之合成與性質研究, 2012生物醫學工程科技研討會暨國科會醫學工程學門成果發表會, , 101年11月17-18日,中原大學, 桃園,中華民國, 2012。

12. Y.C. Fu, C.H. Chen, S.C. Chien, J.K. Chang, M.L. Ho, C.K. Wang, Porous bioceramics were fabricated using reversed thermo-responsive hydrogel as template and combined with rhBMP-2 carriers, 12th-Asian BioCeramics Symposium, 101年11月18-21日, at National Cheng Kung University (NCKU), Tainan, 2012.

13. 王志光,傅尹志,何美泠,戴亦辰,史秉修,鄭添祿,具PEG免疫抗體標的的奈米 PEG-PLGA基質載體之研究, 2011國際臨床工程及醫學資訊研討會暨國科會醫學工程學門成果發表會, 100年12月3日,成功大學,台南,台灣,中華民國, 2011。

14. Szu Hsien Chen, Zheng-Wei Liu, Ching-Ting Tsao, Chih-Kuang Wang, Kuo-Kuang Hsieh*, Synthesis of thermal-responsive chitin-based polyurethane as a smart material, 2011 Annual meeting of Taiwan society for chitin and chitosan, Taiwan.

15. Li-Wen Chen, Ping-Hsiu Shih, Yin-Chih Fu, Chih-Kuang Wang*,Thermo-sensitive hydrogel scaffold of poly(N-isopropylacrylamide) base on 3D cell culture applications, 生物醫學工程2010年研討會, 100年8月18-20日, 成功大學, 台南, 台灣, 中華民國, 2011。

16. 陳立瑋,史秉修,傅尹志,王志光*,Preparation and Characterization of Thermo-responsive Hydrogels on Polylysine mediate Hyaluronic Acid, 中國化學會99年年會, 99年12 月3-5日, 台灣大學, 台北, 台灣, 中華民國, 2010。

17. 簡士強, 傅尹志, 陳立瑋, 何美泠, 王昭仁, 王志光*, 溫感水膠製備多孔性生物陶瓷複合藥物奈米載體於骨礦化之研究,生物醫學工程2010年研討會, 99年12月10-11日, 義守大學, 高雄, 台灣, 中華民國, 2010。

18. 王志光*, 傅尹志, 何美泠, 史秉修, 郭怡君,體溫感應型生物水膠支架之製備與性質,生物醫學工程2009年研討會, 98年12月11-12日, 陽明大學, 台北, 台灣, 中華民國, 2009。

19. 羅紹萍, 陳炳宏, 王志光*, Novel micelle-like nanoparticles made from cationic molecules grafted PLGA copolymers for gene transfection, 中國化學會98年年會, 98年12 月4-6日, 義守大學, 高雄, 台灣, 中華民國, 2009。

20. Y.C. Fu, C.K. Wang, J.K. Chang, M.L. Ho, Development of novel control release system of bone graft for biological activity materials, 中華民國骨科醫學會97年度學術研討會, 97年10月25-26日, 長庚大學, 桃園, 台灣, 中華民國, 2008。

21. 傅尹志, 蔡宗憲, 陳思賢, 何美泠, 鄭寶樹, 王志光*, 新熱敏感型多孔水膠支架之製備與性質,生物醫學工程2008年研討會, 97年12 月12-13日, 長庚大學, 桃園, 台灣, 中華民國, 2008。

22. C.K. Wang*, Shang-Ren Huang, Yi-Jie Li,Study of Novel Biodegradable Nanoparticle for Bone-Targeted Carrier based on dendrimer oligopeptides of aspartic acid, PEG and PLGA, 中國化學會97年年會, 97年12 月5-7日, 國立彰化大學, 彰化, 台灣, 中華民國, 2008。

23. L.R. Jheng, S.H.Chen, C.K. Wang, P.S. Cheng*,Synthesis and Properties of WPU/Epoxy/MTMS/Colloid Al2O3 Organic/Inorganic Nanocomposites Materials,中國化學會97年年會, 97年12 月5-7日, 國立彰化師範大學, 彰化, 台灣, 中華民國, 2008。

24. S.C. Wang, S.H. Chen, Y.J. Li, C.K. Wang, P.S. Cheng*, The research of synthesis of the novel organic anti-static and transparent polymer/SiO2 nano-hybrid film, 中國化學會97年年會, 97年12 月, 國立彰化師範大學, 彰化, 台灣, 中華民國, 2008。

25. S.C. Wu, J.K. Chang, C.K. Wang, I.C. Ting, G.J. Wang, M.L. Ho, Cytocompatibility of a noval hyaluronic acid modified biodegradable scaffold with human adipose derived stem cells for application of cartilage tissue engineering Physiology Symposium 2007, Taipei, Taiwan, March 30-31, 2007.

26. 林子群, 何美泠, 陳思賢, 吳順成, 王志光*, “鑄造鹽洗法製作多孔性PLGA-PEI-HA高分子支架特性評估”,生物醫學工程2007年研討會, 96年12 月14-15日, 逢甲大學, 台中, 台灣, 中華民國, 2007。

27. C.H. Yang, S.H. Chen, S.C. Wang,P.S. Cheng, C.K. Wang*, “Preparation and Characterization of Al2O3/Epoxy Nanocomposites via In-situ Polymerization”, 中國化學會96年年會, 96年12 月, 國立清華大學, 新竹, 台灣, 中華民國, 2007。

28. Y.C. Fu*, C.K. Wang, G.T. Lin, M.L. Ho, Developing new biodegradable carrier product for control release of growth factor, 中華民國骨科醫學會96年度學術研討會, 96年10月27-28日, 長庚大學, 桃園, 台灣, 中華民國, 2007。

29. 傅尹志*, 何美泠, 王志光, 王志華, Optimized Bone Regeneration Based on Sustained Release from Three- Dimensional Fibrous PLGA/HAp Composite Scaffolds Loaded with BMP-2, 骨科醫學會第53次聯合學術研討會, 96年10 月27-28日, 長庚大學, 桃園, 台灣, 中華民國, 2007。

30. 陳惠亭*, 張彣伊, 吳珮綾, 陳建勳, 傅尹志, 王志光, 何美泠, 王國照, Poly(lactide-co-glycolide)/ Hydroxylapatite Composite Scaffolds as Protein Drug Delivery System, 2007台灣藥學會年會, 96年12 月08日, 高雄, 台灣, 中華民國, 2007。

31. 王志光*, 傅尹志, 吳欣蓓, 陳怡伶, 何美泠, “二次微乳化法製備PLGA微小球包覆蛋白質之製程與體外釋放研究”, 中國材料科學學會96年年會, 95年11 月24-25日, 國立成功大學, 台南, 台灣, 中華民國, 2006。

32. 王志光*, 丁奕誠, 吳順成, 何美泠, “透明質酸修飾多孔性PLGA支架製程研究與細胞毒性評估”, 中國材料科學學會95年年會, 95年11 月, 國立成功大學, 台南, 台灣, 中華民國, 2006。

33. S.C. Wu, J.K. Chang, C.K. Wang, I.C. Ting, G.J. Wang, M.L. Ho*, “Cytocompatibility of a noval hyaluronic acid modified biodegradable scaffold with human adipose derived stem cells for application of cartilage tissue engineering”, International symposium on recent advances in stem cell research & 2006 annual meeting of Taiwan society for stem cell research, 95年9 月1-2日, 台北醫學大學, 台北, 台灣, 中華民國, 2006。

34. 王志光*, 陳嘉祥, 陳怡伶, 陳惠亭, 傅尹志,王國照, 何美泠, “新型核殼複合微粒包覆蛋白質之研究”, 中國材料科學學會94年年會, 94年11 月25-26日, 私立淡江大學, 台北, 台灣, 中華民國, 2005。

35. 王志光*, 利宛芸, 陳泊余, “氫氧基磷灰石包覆奈米金之殼層複合材料特性研究”, 中國材料科學學會94年年會, 94年11月25-26日, 私立淡江大學, 台北, 台灣, 中華民國, 2005。

36. 王志光*, 陳虹年, 吳順成, 傅尹志, 王國照, 何美泠, “乳化法形成磷酸鈣生物陶瓷微米球之特性研究”, 中國材料科學學會94年年會, 94年11 月25-26日, 私立淡江大學, 台北, 台灣, 中華民國, 2005。

37. 吳順成, 何美泠, 王志光, 王國照*, “Cell adhesion of adipose derived stem cells on three-dimensional poly DL-lactic-co-glycolic acid  scaffold with different pore size”, 中華民國骨科醫學會94年年會,  94年10月18日, 台北榮民總醫院, 台北, 台灣, 中華民國, 2005。

38. 王志光*, 廖駿偉, 張仕欣, 蕭祝螽, 簡育菁, 謝玉霞, 朱時梁 “微波電漿改質奈米二氧化鈦之可見光觸媒特性研究”, 微波電漿奈米製程應用研討會, 92年11 月, 經濟部能源委員會, 高雄, 台灣, 中華民國, 4-1, 2003。

39. 王志光*, 許富銀, 闕山璋, “時效溫度對磷灰石析出及熱穩定研究”, 中國材料科學學會90年年會, 90年11 月, 國立中興大學, 台中, 台灣, 中華民國, P05, 2001。

40. 陳瑾惠, 王志光, 朱建平*, “雷射蒸鍍氫氧基磷灰石薄膜結構、性質及熱處理之影響”,中國材料科學學會86年年會, 國立成功大學, 台南, 台灣, 中華民國, pp. J1-4 1997。

41. 朱建平, 王志光, 陳瑾惠*, “添加生物活性玻璃對氫氧基磷灰石燒結體結構及性質影響”, 中國材料科學學會86年年會, 國立成功大學, 台南, 台灣, 中華民國, pp. J17-20, 1997。

42. 王志光, 朱建平, 陳瑾惠*, “雷射蒸鍍結晶性氫氧基磷灰石,薄膜於鈦基材微結構性質研究", 中華民國84年醫學工程科技研討會, 國立成功大學, 台南,台灣,中華民國, pp.300-301, 1995。

43. 王志光, 朱建平, 陳瑾惠*, “添加生醫玻璃對氫氧基磷灰石燒結強度及微結構之影響”, 中華民國83年醫學工程科技研討會, 國立陽明大學, 台北, 台灣, 中華民國, pp.218-219, 1994。

44. 王志光, 朱建平, 陳瑾惠*, “生醫玻璃及石英強化氫氧基磷灰石研究”, 中國材料科學學會83年年會, 83年4 月, 國立中山大學, 高雄, 台灣, 中華民國, pp. 380-381, 1994。

45. 王志光, 鄭鴻毅, 陳瑾惠, 朱建平*, “短碳纖/碳化矽複合材料之製程及磨耗研究製程及性質研究”, 中國材料科學學會82年年會, 82年4月日30至5月1日, 國立交通大學, 新竹, 台灣, 中華民國, 5-11, 1993。

46. 鄭鴻毅, 王志光, 陳瑾惠, 朱建平*, “短碳纖/碳化矽複合材料之製程及磨耗研究磨耗行為”, 中國材料科學學會82 年年會, 82年4月30日至5月1日, 國立交通大學, 新竹, 台灣, 中華民國, 5-13, 1993。

國內期刊及雜誌論文

01. 王志光*, 許富銀, 張仕欣, 簡育菁, 謝玉霞, 廖駿偉, “混合改質型二氧化鈦奈米光觸媒之特性評估”, J. Ceram. Soc.(陶業) 23: 40-47 2004。

02. 王志光*, “奈米光觸媒之疑慮與醒思”， 工業材料雜誌, 198:69-71, 2003。

03. 王志光*, “以二氧化鈦為主的可見光觸媒發展與基本原理”， 工業材料雜誌, 201:155-163, 2003。

04. 王志光, 朱建平, 陳瑾惠*, “雷射蒸鍍結晶性氫氧基磷灰石薄膜於鈦基材結構研究”, J. Ceram. Soc.(陶業), 1:50-57, 1997.

05. 王志光, 鄭鴻毅, 陳瑾惠, 朱建平*, “短碳纖碳化矽複合材料之製程及磨耗研究I-製程及性質研究”, J. Ceram. Soc.(陶業), 12:5-17, 1993。

06. 鄭鴻毅, 王志光, 陳瑾惠, 朱建平*, “短碳纖碳化矽複合材料之製程及磨耗研究II-磨耗研究”, J. Ceram. Soc.(陶業), 12, 18-31, 1993。

專利

1.    王志光, 潘力誠, 李之昀, 林宏哲, 林哲緯, 劉博倫, 史秉修, 具雙影像追蹤探針之高分子奈米載體及其製備方法(Polymeric nanoparticles with dual images tracking probe and method for manufacturing the same)中華民國專利申請號：第103110625號, March 21, 2014。(美國專利申請中)

2.    王志光, 何美泠, 陳崇桓, 傅尹志, 林佳慧, 李之昀, 張瑞根, 全金螢光共振能量轉移探針及其用途(All gold FRET probe and use thereof), 中華民國專利申請號：第103117242號, May 16, 2014。(美國專利申請中)

3.    Chih-Kuang Wang, Mei-Ling Ho, Yin-Chih Fu, Gwo-Jaw Wang, Je-Ken Chang, “Method for preparing composition comprising porous ceramic with thermo-response hydrogel”, United States Patent under apply 13/080,960, April 6, 2011. United States Patent Application 20110248417 A1 Oct. 13, 2011.

4.    王志光, 何美泠, 傅尹志, 王國照, 張瑞根, “以溫感水膠製備多孔性陶瓷技術”,中華民國專利號：I411595,專利權期間自2013.10.11至2028.10.10止。

5.    Yin-Chih Fu, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang, and Cherng-Chyi Tzeng, Sustained Release Systems and Preparation Method Thereof, United States Patent provisional Application 61/237,696, Oct. 28, 2009 and United States Patent Application 12/832,248 June. 08, 2010. United States Patent Application 20110052691 A1, 2011.

6.    傅尹志, 王志光, 王國照, 何美泠, 張瑞根, 曾誠齊, “藥物緩釋系統及其製備方法”,中華民國專利公開號：第201106989 A1號, March 1, 2011。

7.    08. Yin-Chih Fu, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho, Hui-Ting Chen, Je-Ken Chang, and Cherng-Chyi Tzeng, Controlled release system and manufacturing method thereof, US Patent no. 8,663,677, 2014.

8.    傅尹志, 王志光, 王國照, 何美泠, 陳惠亭, 張瑞根, 曾誠齊, “控制釋放之醫藥組合物及其製備方法”, 中華民國專利號：I 362947,專利權期間自2012.5.1至2027.3.7止。

9.    Chih-Kuang Wang, Fu-Yin Hsu, Shan-Chang Chueh, Jiunn-Woei Liaw, Visible light-induced photocatalyst, US-Patent 7169733, 2007.

10. 王志光, 許富銀, 廖駿偉, 闕山璋, “可見光誘發強氧化強還原光觸媒”,中華民國專利證書號：I229011, 2005。

11. 王志光, 許富銀, 廖駿偉, 闕山璋, “奈米金屬複合半導體光觸媒” , 中華民國專利證書號：第I251507號, 2006。

Book 

1.    Chih-Kuang Wang*, Wen-Cheng Chen, Chun-Cheng Hung, Yin-Chih Fu, Two new routes to form porous bioceramic beads, Bioceramics: Properties, Preparation and Applications, editor: Wolffe Kossler and Jacob Fuchs, Nova Science Publishers, Inc. Hauppauge, NY 11788, 2009. ISBN: 978-1-60741-056-0

2.    Mei-Ling Ho*, Je-Ken Chang, Chung-Hwan Chen, Yin-Chih Fu, Chih-Kuang Wang, Chau-Zen Wang, Rajalakshmanan Eswaramoorthy, Shun-Cheng Wu, Application of adipose derived stem cells for bone and cartilage regeneration, Edited book: Mesenchymal stem cells, editor: Yin Xiao, Nova Science Publishers, Inc., 01 September 2011. ISBN: 978-61324-669-6

Go to top