Professor  Yeh-Long Chen

Lab: Medicinal Synthesis Laboratory N844

Tel: 886-7-3121101 ext. 2684

Fax: 886-7-3125339

E-mail: yeloch@kmu.edu.tw

Education and Experience:

• B.S. in Chemistry, Soochow University, Taipei, Taiwan (1983.9 – 1987.6)

• M.S. in Medicinal Chemistry, Kaohsiung Medical College, Kaohsiung, Taiwan (1987.9 – 1989.6)

• Ph.D. in Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan (1995.9 – 1999.6)

• Instructor, School of Chemistry, Kaohsiung Medical University (KMU) (1991.7 – 1998.7)

• Assistant Professor, School of Chemistry, KMU (1998.8 – 2002.7)

• Associate Professor, Faculty of Medicinal and Applied Chemistry, KMU (2002.8 – 2005.7)

• Professor, Department of Medicinal and Applied Chemistry, KMU (2005.8 – )

• Director, Division of University Affairs Development, Office of Institutional Development, KMU (2006.8 – 2008.7)

• Director, Department of Medicinal and Applied Chemistry, KMU (2008.8 – )

Research Interests:

• Design, synthesis and evaluation of anticancer chemotherapeutic agents for the site-specific activation in tumor tissues

• Design and synthesis of novel heterocyclic or metal-chelator bearing molecules as antimycobacterial agents

Teaching Course:

• Organic Chemistry (Department of Biomedical Science & Environmental Biology and Department of Biotechnology)

• Special Topic of Organic Chemistry (Department of Medical & Applied Chemistry Master’s program)

• Special Topic of Organic Spectroscopy (Department of Medical & Applied Chemistry Master’s program)

Selected Publications:

1. 1.       Liu FC, Yu HP, Chen PJ, Yang HW, Chang SH, Tzeng CC, Cheng WJ, Chen YR, Chen YL,* Hwang TL* “A novel NOX2 inhibitor attenuates human neutrophil oxidative stress and ameliorates inflammatory arthritis in mice” Redox Biology, 2019, 26, 101273. (SCI, IF₂₀₁₈ = 7.793; 28/298, BIOCHEMISTRY & MOLECULAR BIOLOGY)

   2.      Yang CY, Hung YL, Tang KW, Wang SC, Tseng CH, Tzeng CC, Liu PL, Li CY,* Chen YL* “Discovery of 2-Substituted 3-Arylquinoline Derivatives as Potential Anti-Inflammatory Agents Through Inhibition of LPS-Induced Inflammatory Responses in Macrophages” Molecules, 2019, 24(6), 1162/1-1162/19. (SCI, IF₂₀₁₈ = 3.060; 68/172, CHEMISTRY, MULTIDISCIPLINARY)

   3.      Cheng KW, Tseng CH, Tzeng CC, Leu YL, Cheng TC, Wang JY, Chang JM, Lu YC, Cheng CM, Chen IJ, Cheng YA, Chen YL,* Cheng TL* “Pharmacological inhibition of bacterial β-​glucuronidase prevents irinotecan-​induced diarrhea without impairing its antitumor efficacy in vivo” Pharmacological Research, 2019, 139, 41-49. (SCI, IF₂₀₁₈ = 5.574; 18/267,  PHARMACOLOGY & PHARMACY)

   4.      Chien CM, Yang JC, Wu PH, Wu CY, Chen GY, Wu YC, Chou CK, Yseng CH, Chen YL,* Wang LF,* Chiu CC* “Phytochemical Naphtho[1,2-b] furan-4,5-dione Induced Topoisomerase II-mediated DNA Damage Response in Human Non-small-Cell Lung Cancer” Phytomedicine 2019,54, 109-119. (SCI, IF₂₀₁₈ = 4.180; 1/27,  INTEGRATIVE & COMPLEMENTARY MEDICINE)

   5.      Miller DR, Tzeng CC, Farmer T, Keller ET, Caplan S, Chen YS, Chen YL,* Lin MF* “Novel CIL-102 derivatives as potential therapeutic agents for docetaxel-resistant prostate cancer” Cancer Lett. 2018, 436, 96-108. (SCI, IF₂₀₁₇ = 6.491; 29/223, ONCOLOGY)

   10.  Cheng KW, Tseng CH, Yang CN, Tzeng CC, Cheng TC, Leu YL, Chuang YC, Wang JY, Lu YC, Chen YL,* Cheng TL* “Specific Inhibition of Bacterial β-​Glucuronidase by Pyrazolo[4,​3-​c]​quinoline Derivatives via a pH-​Dependent Manner To Suppress Chemotherapy-​Induced Intestinal Toxicity” Med. Chem. 2017, 60, 9222-9238. (SCI, IF₂₀₁₆ = 6.259; 3/59, CHEMISTRY, MEDICINAL)

   11.   Chang WT, Fong Y, Chuang SC, Chou CK, Chou HL, Yang CF, Tseng CH, Chen YL, Chiu, CC “9-​Bis[2-​(pyrrolidin-​1-​yl)​ethoxy]​-​6-​{4-​[2-​(pyrrolidin-​1-​yl)​ethoxy]​phenyl}​-​11H-​indeno[1,2-​c]​quinolin-​11-​one (BPIQ)​, A Quinoline Derivative Inhibits Human Hepatocellular Carcinoma Cells by Inducing ER Stress and Apoptosis” Anti-Cancer Agents Med. Chem. 2017, 17, 692-700. (SCI, IF₂₀₁₆ = 2.598; 30/60, CHEMISTRY, MEDICINAL)

   12.  Fong Y, Wu CY, Chang KF, Chen BH, Chous WJ, Tseng CH, Chen YC, Wang HM, Chen YL*, Chiu CC* “Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non small cell lung cancer cells” Cancer Cell Int. 2017, 17-37. (SCI, IF₂₀₁₆ = 2.740; 121/217, ONCOLOGY)