Shinne-Ren Lin

Professor Shinne-Ren Lin

林信仁 　 　

Lab: Biochemistry Laboratory (N817)

Tel: 886-7-3121101 ext. 2219

Fax: 886-7-3125339

E-mail:shreli@kmu.edu.tw

Education and Experience:

  • B.S., Pharmacy, Kaohsiung medical college, Taiwan (1968)

  • M.S. Institute of Medicine, Kaohsiung medical college, Taiwan (1986)

  • Ph.D., Institute of Medicine , Kaohsiung medical college, Taiwan (1991)

  • KMU Assistant (1969 - 1974)，Instructor (1974 - 1978)，Associate Professor (1978 - 1993)。

  • KMU, Department of Medicinal and Applied Chemistry, Prof. (1993-)

  • KMU , Registrar (1993-2000)

Research Interests:

  • Protein Chemistry

  • The mechanism of Cardiotoxins.

  • Signal transduction

Selected Publications:

A.(2008~)

1.          Chien CM, Yang SH, Yang CC, Chang LS, *Lin SR: Cardiotoxin III induces c-Jun N-terminal kinase-dependent apoptosis in HL-60 human leukemia cells. Cell Biochemistry and Function, 2008 Jan-Feb. 26(1), 111-118. (SCI)

2.          Yang SH, Wu ZZ, Chien CM, Lo YH, Wu MJ, Chang LS, *Lin SR: JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells. Cell Biology and Toxicology,2008 Aug. 24(4), 291-302. (SCI)

3.          Kao PH, Chen KC, Lin SR, *Chang LS: The structural and functional contribution of N-terminal region and His-47 on Taiwan cobra phospholipase A2.Journal of Peptide Science,2008 Mar. 14 (3), 342-348. (SCI)

4.          Chen KC, Chiou YL, Kao PH, Lin SR, *Chang LS: Taiwan cobra cardiotoxins induce apoptotic death of human neuroblastoma SK-N-SH cells mediated by reactive oxygen species generation and mitochondrial depolarization. Toxicon,2008 Mar.51(4), 624-634. (SCI)

5.          Chien CM, Yang SH, Chang LS, *Lin SR: Involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in cardiotoxin III-induced apoptosis in HL-60 cells. Clinical and Experimental Pharmacology and Physiology,2008 Sep. 35 (9), 1059-1064. (SCI)

6.          Yang SH, Chien CM, Chang LS, *Lin SR: Cardiotoxin III-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation in K562 cells.Journal of Biochemical and Molecular Toxicology,2008 May/Jun. 22(3), 209-218. (SCI)

7.          Yang SH, Chien CM, Su JC, Chen YL, Chang LS, *Lin SR: Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells. Journal of Biochemical and Molecular Toxicology,2008 Nov. 22(6), 396-404. (SCI)

8.          Chiou YL, Lin SR, *Chang LS: Mutations on N-terminal region of Taiwan cobra phospholipase A(2) result in structurally distorted effects. Journal of Peptide Science,2008 Aug. 14(8), 890-897. (SCI).

9.          Lo YH, Lin CC, Lin CF, Lin YT, Duh TH, Hong YR, Yang SH, Lin SR, Yang SC, Chang LS, *Wu MJ: 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents. Journal of Medicinal Chemistry,2008 May. 51(9), 2682-2688. (SCI)

10.      Chen KC, Lin SR, *Chang LS: Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells. Toxicon,2008 Aug. 52(2), 361-368. (SCI)

11.      Chen KC, Kao PH, Lin SR, *Chang LS: p38 MAPK activation and mitochondrial depolarization mediate the cytotoxicity of Taiwan cobra phospholipase A2 on human neuroblastoma SK-N-SH cells. Toxicology Letters,2008 Jul. 180(1), 53-58. (SCI)

12.      Chien CM, Yang SH, Lin KL, Chen YL, Chang LS, *Lin SR: Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells. Chemico-Biological Interactions,2008 Oct. 176(1), 40-47. (SCI)

13.      Tseng KF, Lin CF, Lo YH, Hu YL, Chen LY, Yang SH, Lin SR, Chang LS, *Wu MJ: Synthesis and biological evaluation of novel symmetry bis-enediynes. European Journal of Medicinal Chemistry,2009 Jan. 44(1), 35-41. (SCI)

14.      Chiu CC, Lin KL, Chien CM, Chang LS, *Lin SR: Effects of cardiotoxin III on NF-kappaB function, proliferation, and apoptosis in human breast MCF-7 cancer cells. Oncology Research,2009 Sep. 17(7), 311-321. (SCI)

15.      Chen KC, Kao PH, Lin SR, *Chang LS: Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation. Journal of Cellular Biochemistry,2009 Jan. 106(1), 93-102. (SCI)

16.      Liu WH, Kao PH, Lin SR, *Chang LS: Membrane-damaging activity with A chain and B chain of beta-bungarotoxin. Toxicon,2009 Feb. 53(2), 262-268. (SCI)

17.      Liu WH, Kao PH, Chiou YL, Lin SR, Wu MJ, *Chang LS: Catalytic activity-independent pathway is involved in phospholipase A(2)-induced apoptotic death of human leukemia U937 cells via Ca(2+)-mediated p38 MAPK activation and mitochondrial depolarization. Toxicology Letters,2009 Mar. 185(2), 102-109. (SCI)

18.      Kao PH, Lin SR, *Chang LS: Differential binding to phospholipid bilayers modulates membrane-damaging activity of Naja naja atra cardiotoxins.Toxicon,2009 Sep. 54(3), 321-328. (SCI)

19.      Kao PH, Lin SR, Wu MJ, *Chang LS: Membrane-bound conformation and phospholipid components modulate membrane-damaging activity of Taiwan cobra cardiotoxins. Toxicon,2009 Apr. 53(5), 512-518. (SCI)

20.      Su JC, Lin KL, Chien CM, Lu CM, Chen YL, Chang LS, *Lin SR: Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. Life Sciences,2009 Sep. 85(13-14), 505-516. (SCI)

21.      Chien CM, Lin KL, Su JC, Chang LS, *Lin SR: Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra. Journal of Natural Products,2009 Oct. 72(10), 1735-1740. (SCI)

22.      Tu YS, Duh TH, Tseng CY, Lin YT, Lo YH, Hu YL, Chen CH, Chien CM, Yang SH, Lin SR, Yang SC, *Wu MJ: 1-(2-((Z)-6-(2-(Trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperid- in-2-one as a new potent apoptosis agent. Bioorganic and Medicinal Chemistry,2009 Nov.17(21), 7412-7417. (SCI)

23.      Ping SY, Hour TC, Lin SR, *Yu DS: Taxol synergizes with antioxidants in inhibiting hormal refractory prostate cancer cell growth. Urologic Oncology,2010 Mar-Apr. 28 (2), 170-179. (SCI)

24.      Lin KL, Su JC, Chien CM, Tseng CH, Chen YL, Chang LS, *Lin SR: Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation. Toxicol in Vitro,2010 Feb. 24(1), 61-70. (SCI)

25.      Su JC, Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, *Lin SR: Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells. Life Sciences,2010 Jan. 86(5-6), 207-213. (SCI)

26.      Lin KL, Su JC, Chien CM, Chuang PW, Chang LS, *Lin SR: Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells. Toxicon,2010 Jun. 55(7), 1263-1273. (SCI)

27.      Lin KL, Su JC, Chien CM, Tseng CH, Chen YL, Chang LS,* Lin SR: Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells. Toxicol in Vitro,2010 Jun.24(4), 1158-1167. (SCI)

28.      Kao PH, Lin SR, *Chang LS: Interaction of Naja naja atra cardiotoxin 3 with H-trisaccharide modulates its hemolytic activity and membrane-damaging activity. Toxicon,2010 Jun. 55(7), 1387-1395. (SCI).

29.      Chien CM, Lin KL, Su JC, Chuang PW, Tseng CH, Chen YL, Chang LS,*Lin SR: Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway. European Journal of Pharmacology,2010 Jun. 636 (1-3), 52-58. (SCI)

30.      *Chiu CC, Chen JY, Lin KL, Huang CJ, Lee JC, Chen BH, Chen WY, Lo YH, Chen YL, Tseng CH, *Chen YL, Lin SR: p38 MAPK and NF-kappaB pathways are involved in naphtho[1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells. Cancer Letters,2010 Sep.295(1), 92-99. (SCI)

31.      Su JC, Lin KL, Chien CM, Chuang PW, Chang LS, *Lin SR: Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3-kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III-treated A549 cells. Clinical and Experimental Pharmacology and Physiology,2010 Aug. 37(8), 833-840. (SCI)

32.      Chien CM, Chang SY, Lin KL, Chiu CC, Chang LS, *Lin SR: Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon,2010 Sep. 56(4), 508-520. (SCI)

33.      Chiou YL, Kao PH, Liu WH, Lin SR, *Chang LS: Roles of lysine residues and N-terminal alpha-amino group in membrane-damaging activity of Taiwan cobra cardiotoxin 3 toward anionic and zwitterionic phospholipid vesicles. Toxicon,2010 Feb-Mar. 55(2-3), 256-264. (SCI)

34.      Liu WH, Chen KC, Chiou YL, Lin SR, *Chang LS: Taiwan cobra phospholipase A2 elicits posttranscriptional up-regulation of ADAM17 in human neuroblastoma SK-N-SH cells. Journal of Cellular Biochemistry,2010 Sep. 111(1), 148-157. (SCI)

35.      Tseng CH, Chen YL, Yang SH, Peng SI, Cheng CM, Han CH, Lin SR, *Tzeng CC: Synthesis and antiproliferative evaluation of certain iminonaphtho[2,3-b]furan derivatives. Bioorganic and Medicinal Chemistry,2010 Jul. 18(14), 5172-5182. (SCI)

36.      Chiou YL, Lin SR, *Chang LS: Lipid domain formation modulates activities of snake venom phospholipase A(2) enzymes. Toxicon,2010 Dec. 56(8), 1362-1371. (SCI)

37.      Su JC., Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, *Lin SR: Furano-1, 2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells. Cell Biochemistry and Function, 2010 Dec. 28(8), 695-705.  (SCI)

38.      Kao PH, Chiou YL, Lin SR, *Chang LS: Guanidination of notexin alters its membrane-demaging activity in response to shingomyelin and cholesterol.Journal of Biosciences, 2010 Dec. 35(4), 583-593. (SCI)

B.

1.          Chen YL, Huang CJ, Huang ZY, Tzeng CH, Chang FS, Yang SH, Lin SR, Tzeng CC, 2006: Synthesis and antiproliferative activity of 2-substituted 4- anilinoquinolines. The 8th International Symposium on Organic Reactions. Apr. Japan, Kobe. P24.

2.          Wu Z Z, Lu YJ, Yang SH, Chien CM, Wu MJ, Lin SR, 2006: Molecular mechanisms of THDA, a novel enediyne derivative, induced apoptosis in K562 cells. The Annual Meeting of Chinese Chemical Society, Nov. Taoyuan.

3.          Lu YJ, Wu ZZ, Yang SH, Chien, CM, Wu MJ, Lin SR, 2006: The antitumor effect and mechanism of G2/M phase arrest and apoptosis by novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. The Annual Meeting of Chinese Chemical Society, Nov. Taoyuan.

4.          Yang SH, Chien CM, Su JC, Chen YL, Lin SR, 2007: IQDMA induced apoptosis through blockage of Jak-STAT pathway and activation of JNK in K562 cells. The Annual Meeting of Chinese Chemical Society, Dec. HsinJu..

5.          Su JC, Chien CM, Lin KL, Chuang PW, Chen YL, Lin SR, 2008. Cytotoxic study of a synthetic compound, naphtho[1,2-b]furan-4,5-dione, against A 549 cells. The Annual Meeting of Chinese Chemical Society, Dec. Chang-Hua.

6.          Chien CM, Tseng YS, Chuang PW, Cheng SY, Wang CH, Su YH, Chang SC, Lin SR, 2009. Cardiotoxin III induces apoptosis in oral squamous cell carcinoma Ca9-22 cells. The Annual Meeting of Chinese Chemical Society, Dec. I-Shou.

7.          Su JC, Shiue TT, Cheng YC, Chen YL, Lin SR, 2009. Inactivates EGFR and PI3K/Akt signaling pathways by Naphtho[1,2-b]furan-4,5-dione in human lung adenocarcinoma A549 cells. The Annual Meeting of Chinese Chemical Society, Dec. I-Shou.

8.          Lin KL, Cheng SY, Wang CF, Su YH, Chang SC, Tseng YS, Chen YL, Lin SR, 2009. Naphtho[1,2-b]furan-4,5-dione induces apoptosis in human breast MDA-MB-231 cancer cells. The Annual Meeting of Chinese Chemical Society, Dec. I-Shou.

9.          Su JC, Cheng YC, Shiue TT, Lin SR, 2009.Concomitant inactivation of the EGFR, PI3K/Akt, and JAK2/STAT signaling pathways in cardiotoxin III-treated A549 cells. The Chinese Society of Cell and Molecular Biology, Jan. Kenting.

10.      Lin. KL, Chien CM, Tseng YS, Chuang PW, Wang CF, Chang SC, Su YH, Chen SY, Chen YL, Lin SR, 2010 . Down-regulation of JNK/MAPK activation is associated with the Naphtho[1,2-b]furan-4,5-dione –induced apoptosis in human breast MDA-MB-231 cancer cells. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Feb. Kaohsiung.

11.      Lin KL, Chien CM, Tseng YS, Chuang PW, Su YH, Wang CF, Chang SC, Chen SY, Chen YL, Lin SR, 2010 . The JAK/STAT pathway is critical for Naphtho[1,2-b]furan-4,5-dione -induced apoptosis to prevent MDA-MB-231 cells. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Feb. Kaohsiung.

12.      Lin KL, Chien CM, Tseng YS, Chuang PW, Chang SC, Su YH, Wang CF, Chen SY, Chen YL, Lin S R, 2010 . Cardiotoxin III induces apoptosis via inhibition of JAK2/STAT3 signaling pathway in human breast cancer cells. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Feb. Kaohsiung.

13.      Tseng YS, Chien CM, Lin KL, Su JC, Chuang PW, Su YH, Wang CF,Chang SC, Chen YL, LinSR, 2010. Naphtho[1,2-b]furan-4,5-dione induces apoptosis via epidermal growth factor receptor signaling pathway in oral squamous cell carcinoma Ca9-22 cell. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Feb. Kaohsiung.

14.      Chien CM, Tseng YS, Lin KL, Chuang PW, Su YH, Wang CF,Chang SC, Chen YL, LinSR, 2010. CTX III, as a EGF Receptor inhibitor, induces mitochondria-dependent apoptosis in Ca9-22 cells.CTX III, as a EGF Receptor inhibitor, induces mitochondria-dependent apoptosis in Ca9-22 cells. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Feb. Kaohsiung.

15.      Chien CM, Tseng YS, Lin KL, Chuang PW, Su Y H, Wang CF,Chang SC, Chen YL,Lin SR, 2010. Naphtho[1,2-b]furan-4,5-dione induces G2/M arrest involving inhibition of phosphorylation of  Src in Ca9-22 cells. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Feb.Kaohsiung.  

16.      Su JC, Cheng YC, Shiue TT, Chen YL, Lin SR, 2010. IQDMA induces G2/M-phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Feb. Kaohsiung.

17.      Su JC, Shiue TT, Cheng YC, Tseng CH, Chen YL, Lin SR, 2010. Naphtho[1,2-b]furan-4,5-dione induces G2/M cell cycle arrest and apoptosis in A549 cells. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Feb. Kaohsiung.

18.      Hsieh CY, Tsai PC, Lin KL, Chang LS, Lin SR, 2010. Signal transduction pathways involved in the naphtho[1,2-b]furan-4,5-dione–induced apoptosis in human breast MDA-MB-231 cancer cells. The 2010 South Taiwan Biotechnology Exposition, Oct. Kaohsiung.

19.      Tsai PC, Hsieh CY, Lin KL, Chang L.S, Lin SR, 2010. Antimetastatic potential and application of cardiotoxin III (CTX III) in MDA-MB-231 human breast cancer cells. The Annual Meeting of Chinese Chemical Society, Dec. Taipei.

20.      Lin KL, Chang LS, Lin SR, 2011. Signal transduction pathways involved in the Cardiotoxin III-inhibited metastasis in human breast MDA-MB-231 cancer cells. Triple Negative Breast Cancer Conference 2011, Mar. London.

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