Assistant Professor Wei-Yu Lin

林韋佑    

Lab: Comprehensive laboratory building 404

TEL: +886-7-3121101 ext. 2807

Fax: +886-7-3125339

E-mail: Wylin@kmu.edu.tw

Microfluidic chemical laboratory

Education:

  • National Cheng Kung University, Department of Chemistry, B. S. (1998)
  • National Taiwan University, Department of Chemistry, M. S. (2001)
  • National Taiwan University, Department of Chemistry, Ph. D (2006)

Research interests:

  • Organic synthesis chemistry
  • Microfluidic biochips
  • Micro-sensors
  • Nano-Biomaterials Design and Synthesis
  • Design of Biological orthogonal reactions, and the appilication in medical chemistry 

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Publications:

1.  Chen, K. J.; Tang, L.; Garcia, M. A.; Wang, H.; Lu, H.; Lin, W.-Y.; Hou, S.; Yin, Q.; Shen, C. K.; Cheng, J.; Tseng, H. R., The therapeutic efficacy of camptothecin-encapsulated supramolecular nanoparticles. Biomaterials 2012, 33, 1162-9.

2.  Liu, K.; Lepin, E. J.; Wang, M. W.; Guo, F.; Lin, W.-Y.; Chen, Y. C.; Sirk, S. J.; Olma, S.; Phelps, M. E.; Zhao, X. Z.; Tseng, H. R.; Michael van Dam, R.; Wu, A. M.; Shen, C. K., Microfluidic-based 18F-labeling of biomolecules for immuno-positron emission tomography. Molecular imaging 2011, 10, 168-76, 1-7.

3.  Hou, S.; Phung, D. L.; Lin, W.-Y.; Wang, M. W.; Liu, K.; Shen, C. K., Microwave-assisted one-pot synthesis of N-succinimidyl-4[ 18F]fluorobenzoate ([(18F]SFB). Journal of visualized experiments : JoVE 2011.

4.  Wang, S.; Chen, K. J.; Wu, T. H.; Wang, H.; Lin, W.-Y.; Ohashi, M.; Chiou, P. Y.; Tseng, H. R., Photothermal effects of supramolecularly assembled gold nanoparticles for the targeted treatment of cancer cells. Angew. Chem. Int. Ed. 2010, 49, 3777-81.

5.  Wang, M. W.; Lin, W.-Y; Liu, K.; Masterman-Smith, M.; Kwang-Fu Shen, C., Microfluidics for positron emission tomography probe development. Molecular imaging2010, 9, 175-91.

6.  Wang, H.; Liu, K.; Chen, K. J.; Lu, Y.; Wang, S.; Lin, W.-Y.; Guo, F.; Kamei, K.; Chen, Y. C.; Ohashi, M.; Wang, M.; Garcia, M. A.; Zhao, X. Z.; Shen, C. K.; Tseng, H. R., A rapid pathway toward a superb gene delivery system: programming structural and functional diversity into a supramolecular nanoparticle library. ACS nano 2010, 4, 6235-43.

7.  Liu, K.; Wang, H.; Chen, K. J.; Guo, F.; Lin, W.-Y.; Chen, Y. C.; Phung, D. L.; Tseng, H. R.; Shen, C. K., A digital microfluidic droplet generator produces self-assembled supramolecular nanoparticles for targeted cell imaging. Nanotechnology 2010, 21, 445603.

8.  Fang, C.; Wang, Y.; Vu, N. T.; Lin, W.-Y.; Hsieh, Y. T.; Rubbi, L.; Phelps, M. E.; Muschen, M.; Kim, Y. M.; Chatziioannou, A. F.; Tseng, H. R.; Graeber, T. G., Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples. Cancer research 2010, 70, 8299-308.

9.  Wang, Y. J*.; Lin, W.-Y*.; Liu, K.; Lin, R. J.; Selke, M.; Kolb, H. C.; Zhang, N. G.; Zhao, X. Z.; Phelps, M. E.; Shen, C. K. F.; Faull, K. F.; Tseng, H. R., An integrated microfluidic device for large-scale in situ click chemistry screening. Lab Chip 2009, 9, 2281-85. (*equal contribution)

10.  Wang, H.; Wang, S. T.; Su, H.; Chen, K. J.; Armijo, A. L.; Lin, W.-Y.; Wang, Y. J.; Sun, J.; Kamei, K.; Czernin, J.; Radu, C. G.; Tseng, H. R., A Supramolecular Approach for Preparation of Size-Controlled Nanoparticles. Angew. Chem. Int. Ed. 2009, 48, 4344-48.

11.  Lin, W.-Y.; Wang, Y.; Wang, S.; Tseng, H. R., Integrated Microfluidic Reactors. Nano today 2009, 4, 470-81.

12.  Hou, S.; Wang, S.; Yu, Z. T. F.; Zhu, N. Q. M.; Liu, K.; Sun, J.; Lin, W.-Y.; Shen, C. K. F.; Fang, X.; Tseng, H. R., A hydrodynamically focused stream as a dynamic template for site-specific electrochemical micropatterning of conducting polymers. Angew. Chem. Int. Ed. 2008, 47, 1072-75.

13.  Coti, K. K.; Wang, Y.; Lin, W.-Y.; Chen, C. C.; Yu, Z. T. F.; Liu, K.; Shen, C. K. F.; Selke, M.; Yeh, A.; Lu, W. X.; Tseng, H. R., A dynamic micromixer for arbitrary control of disguised chemical selectivity. Chem Commun 2008, 3426-28.

14.  Lin, W.-Y.; Wang, H. W.; Liu, Z. C.; Xu, J.; Chen, C. W.; Yang, Y. C.; Huang, S. L.; Yang, H. C.; Luh, T. Y., On the tacticity of polynorbornenes with 5,6-endo pendant groups that contain substituted aryl chromophores. Chem-Asian J. 2007, 2, 764-74.

15.  Lin, H. C.; Lin, W.-Y.; Bai, H. T.; Chen, J. H.; Jin, B. Y.; Luh, T. Y., A bridging double bond as an electron acceptor for optical nonlinearity of furan-containing [n.2]cyclophenes.Angew. Chem. Int. Ed. 2007, 46, 897-900.

16.  Lin, W.-Y.; Murugesh, M. G.; Sudhakar, S.; Yang, H. C.; Tai, H. C.; Chang, C. S.; Liu, Y. H.; Wang, Y.; Chen, I. W. P.; Chen, C. H.; Luh, T. Y., On the rigidity of polynorbornenes with dipolar pendant groups. Chem-Eur J 2006, 12, 324-30.

17.   Luh, T. Y.; Chen, R. M.; Hwu, T. Y.; Basu, S.; Shiau, C. W.; Lin, W.-Y.; Jin, B. Y.; Hsu, C. C., Rational design of polymers for optoelectronic interests. Pure Appl Chem 2001, 73, 243-46.

Conference paper:

  1. Lin, W.-Y.; Wang, Y.; Chen, Y.-C.; Hou, S.; Satyamurthy, N.; Phelps, M. E.; Tseng, H.-R., “Integrated Microfluidic Devices for Sequential Synthesis of Molecular Imaging Probes", Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007, ORGN-45
  2. Wang, Y.; Lin, W.-Y.; Phelps, M. E.; Kolb, H. C.; Tseng, H.-R., “Parallel Screening of an In Situ “click" Chemistry Library in Integrated Microfluidics", Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007, ORGN-455.
  3. Olma, S.; Liu, K.; Lin, W.-Y.; Chen, Y. -C.; Faull, K. Desiome, J.; Wu, A.; van Dam , M.; Shen, K.-F.; Tseng, H.-R.; Phelps, M. E. “Nanotechnology-Derived Positron-Emitting Probes for Molecular Imaging", NCI Alliance for Nanotechnology in Cancer Bulletin, 2008,
  4. Lin, W.-Y.; Wang, Y.; Lin, R.; Phelps. M. E.; Shen, K. -F. C; Tseng, H.-R. “Parallel Screening of in situ Click Chemical Libraries in Integrated microfluidics”, pp. 1314. 12Th international conference on Miniaturized systems for chemistry and life sciences, San Diego, CA, United States,  October 2008.
  5. Lin, W.-Y.; Liu, K. Wang, H.; Girgis,, M. M.; McCracken M.; Tseng, H.-R.; Tomlinson, J. S.; Wu, A. M.; Shen, K. -F. C; “ Bioorthogonal 18F-labeling of Biomolecules via Inverse Electron Demand Diels-Alder Cycloaddition”, S987. 2010 World Molecular Imaging Congress, Kyoto, Japan, September 2010.
  6. Liu, K.; Lepin, E. J.; Wang, M. Lin, W. -Y.; Tseng, H.-R.; Wu, A. M.; Shen, K. -F. C;“Using digital microfluidics to optimize 18F-labeling conditions of diabodies”, S1012. 2010 World Molecular Imaging Congress, Kyoto, Japan, September 2010
  7. Hou, S. Lin, W. -Y.; Wang, H. Tseng, H.-R.; Shen, K. -F. C;“ Supramolecular Nanoparticle (SNP) as a Cancer Imaging Agent Visualized by Bioorthogonal Ligation”, P066. 2011 World Molecular Imaging Congress, San Diego, CA,
    September 2011
  8. Lin, W. -Y.; Hou, Shuang, Li, K.-P.; Shen D. H.; Shen, K. -F. C;“ Divergent Synthesis of 18F-Tags for Bioorthogonal Labeling via Strain-Promoted Azide
    Dibenzocycloazaoctyne Cycloaddition”, S180. 2011 World Molecular Imaging Congress, San Diego, CA, September 2011

Patent:
    Tseng, H. -R; Wang, J.; Sui, G.; Faull, K.; Wang, Y.; Lin, W.-Y
Integrated Microfluidic Platform for Parallel Screening of a Chemical Library.
PCT Int. Appl, WO 2009009021, 2009.

Patents book:

   Wang, Y.; Lin, W. -Y.; Yu, Z. T. F.; Tseng, H.-R.
Microfluidic Reactors for Sequential and Parallel reactions
Biological Applications of Microfluidic (Editor: Gomez, F. A.) [Chapter 9] Publisher: Wiley VCH. New York, 2009.

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