Professor M. Y. Chang

Lab: N837

Tel: 886-7-3121101 ext. 2220

Fax: 886-7-3125339

E-mail:mychang@kmu.edu.tw

Education and Experence

• BS. Department of Chemistry, National Sun Yat-sen University

• PhD. Department of Chemistry, National Sun Yat-sen University

• Postadoc. Institute of Biological Chemistry, Acadamia Sinica

• Assistant Professor, Department of Applied Chemistry, National

  University of Kaohsiung

• Associate Professor, Department of Applied Chemistry, National

  University of Kaohsiung  

• Assistant Professor and chairman, Department of Applied Chemistry,

  National University of Kaohsiung

• Chief Research Chemist, Potoresist Technical Department, Eternal

  Chemical CO., LTD

• Professor and chairman, Department of Applied Chemistry,National University of Kaohsiung

Recent Publications:

§  Chang, M.-Y.*; Chen, H.-Y.; Tsai, Y.-L. Org. Lett. 2019, 21, 1832-1836. “NH₂OH-HCl Mediated Umpolung α-Methylsulfonylation of α-Sulfonyl Ketones with Methylsulfoxides. Synthesis of α,β-Bis-sulfonyl Arylketones”

§  Chang, M.-Y.*; Chen, H.-Y.; Tsai, Y.-L. J. Org. Chem. 2019, 84, 326-337. “Temperature-Controlled Desulfonylative Condensation of α-Sulfonyl o-Hydroxyacetophenones and 2-Formyl Azaarenes. Synthesis of 2-Azaaryl Aurones and Flavones” 

§  Chang, M.-Y.*; Chen, H.-Y.; Tsai, Y.-L. J. Org. Chem. 2019, 84, 443-449. “Intramolecular Benzannulation of 3-Sulfonyl-2-benzylchromen-4-ones. Synthesis of Sulfonyl Dibenzooxabicyclo[3.3.1]nonanes”

§  Chang, M.-Y.*; Wu, Y.-S. J. Org. Chem. 2019, 84, 3638-3646. “HOAc-Mediated Cyclocondensation of 2-Formylazaarenes and Cyclic Amines. Synthesis of Pyrrolo[1,2-a]azaarenes”

§  Chang, M.-Y.*; Wu, Y.-S.; Chen, H.-Y. Org. Lett. 2018, 20, 1824-1827. “CuI Mediated Synthesis of Sulfonyl Benzofuran-3-ones and Chroman-4-ones”   

§  Chang, M.-Y.*; Chen, Y.-H.; Wang, H.-S. J. Org. Chem. 2018, 83, 2361-2368. “Cu(OAc)₂ Mediated Synthesis of 3-Sulfonyl Chromen-4-ones”  

§  Chang, M.-Y.*; Tsai, Y.-L. J. Org. Chem. 2018, 83, 6798-6804. “Stereocontrolled Synthesis of 3-Sulfonyl Chroman-4-ols” 

§  Hsueh, N.-C.; Lai, K.-S.; Chang, M.-Y.* J. Org. Chem. 2018, 83, 11415-11424. “Stereocontrolled Construction of 1-Vinylindanes via Intramolecular Cyclization of o-Cinnamyl Chalcones” 

§  Chang, M.-Y.*; Hsiao, Y.-T.; Lai, K.-S. J. Org. Chem. 2018, 83, 14110-14119. “mCPBA-Mediated Intramolecular Oxidative Annulation of ortho-Crotyl or Cinnamyl Arylaldehydes. Synthesis of Benzofused Five-, Six- and Seven-Membered Oxacycles” 

§  Chan, C.-K.; Tsai, Y.-L.; Chang, M.-Y.* Org. Lett. 2017, 19, 1358-1361.“Construction of Nitrated Benzo[3.3.1]bicyclic Acetal/ketal Core via Nitration of o-Carbonyl Allylbenzenes”

§  Chan, C.-K.; Tsai, Y.-L.; Chang, M.-Y.* Org. Lett. 2017, 19, 1870-1873. “CuI Mediated One-pot Cycloacetalization/Ketalization of o-Carbonyl Allylbenzenes: Synthesis of Benzobicyclo[3.2.1]octane Core”

§  Chan, C.-K.; Chen, Y.-H.; Tsai, Y.-L.; Chang, M.-Y.* J. Org. Chem. 2017, 82, 3317-3326. “Synthesis of Substituted 1,6-Diarylnaphthalenes via a Tandem Claisen Rearrangement and Ene Reaction Protocol”

§  Chan, C.-K.; Hsueh, N.-C.; Tsai, Y.-L.; Chang, M.-Y.* J. Org. Chem. 2017, 82, 7077-7084. “Bi(OTf)₃ Mediated Intramolecular Olefinic Cyclization: Synthesis of Substituted Aryl-Dihydronaphthalenes and Indenes”

§  Chang, M.-Y.*; Chen, H.-Y.; Wang, H.-S. J. Org. Chem. 2017, 82, 10601-10610. “Regiocontrolled Synthesis of α-Sulfonylmethyl o-Nitrostyrenes via ZnI₂-Mediated Sulfonylation and AgNO₂/Pd(PPh₃)₄-Promoted o-Nitration”

§  Chang, M.-Y.*; Hsiao, Y.-T. J. Org. Chem. 2017, 82, 11594-11602. “H₂SO₄ Mediated Stereocontrolled Annulation of Sulfonyl 4-Alkenols and Oxygenated Naphthalenes: One-Pot Synthesis of Sulfonyl Tetanthrenes”

§  Chang, M.-Y.*; Chen, H.-Y.; Chen, Y.-H. J. Org. Chem. 2017, 82, 12631-12639. “Synthesis of 2-Aryl-3-Sulfonylchromans via Knoevenagel Condensation and Reduction Protocol”

§  Hsueh, N.-C.; Chen, H.-Y.*; Chang, M.-Y.* J. Org. Chem. 2017, 82, 13324-13332. “Construction of Sulfonyl Oxabenzo[3.3.1]bicyclic Core via Cyclocondensation of β-Ketosulfones and o-Formyl Allylbenzenes” 

§  Chang, M.-Y.*; Cheng, Y.-C. Org. Lett. 2016, 18, 608-611. “Synthesis of Substituted Tetralins and Benzosuberans via BF₃·OEt₂ Mediated Formal (4+2) and (5+2) Stereocontrolled Cycloaddition of 4-Alkenols with Veratrol”

§  Chang, M.-Y.*; Cheng, Y.-C. Org. Lett. 2016, 18, 1682-1685. “Synthesis of Substituted 1-Aryltetralins and 1-Arylnaphthalenes via (4+2) Annulation of β-Ketosulfones with Styryl Bromides”

§  Chan, C.-K.; Chan, Y.-L.; Tsai, Y.-L.; Chang, M.-Y.* J. Org. Chem. 2016, 81, 8112-8120. “One-Pot Synthesis of 2-Cyano-1,4-diketones: Applications to Synthesis of Cyanosubstituted Furans, Pyrroles and Dihydropyridazines”

§  Chan, C.-K.; Tsai, Y.-L.; Chan, Y.-L.; Chang, M.-Y.* J. Org. Chem. 2016, 81, 9836-9847. “Synthesis of Substituted 2,3-Benzodiazepines”

§  Chang, M.-Y.*; Cheng, Y.-C.; Lu, Y.-J. Org. Lett. 2015, 17, 1264-1267. “Bi(OTf)₃-Mediated Cycloisomerization of γ-Alkynyl Arylketones: Application to the Synthesis of Substituted Furans”

§  Chang, M.-Y.*; Cheng, Y.-C.; Lu, Y.-J. Org. Lett. 2015, 17, 3142-3145. “Synthesis of Substituted Benzenes via Bi(OTf)₃-Mediated Intramolecular Carbonyl Allylation of α-Prenyl or α-Gernyl β-Arylketosulfones”

§  Chang, M.-Y.*; Cheng, Y.-C. Org. Lett. 2015, 17, 5702-5705. “Bi(OTf)₃ Mediated Exo-Olefin Isomerization of α-Benzoyl β-Styrylsulfones”

§  Chang, M.-Y.*; Cheng, Y.-C.; Lu, Y.-J. Org. Lett. 2014, 16, 6252-6255. “One-pot Access to Sulfonylmethyl Arylpyrroles via the Domino Aerobic Wacker-type Aminocyclization/1,4-Sulfonyl Migration”

§  Chang, M.-Y.*; Wu, M.-H.; Chen, Y.-L. Org. Lett. 2013, 15, 2822-2825. “One-pot Synthesis of Substituted Tetrahydrocyclobuta[a]naphthalenes by Domino Aldol Condensation/Olefin Migration/Electrocyclization”  

§  Chang, M.-Y.*; Lee, T.-W.; Wu, M.-H. Org. Lett. 2012, 14, 2198-2201. “Polyphosphoric Acid Promoted Synthesis of Tetrahydrobenzo[j]fluoranthen-12-one”

§  Chang, M.-Y.*; Wu, M.-H.; Tai, H.-Y. Org. Lett. 2012, 14, 3936-3939. “NH₄OAc Mediated Cyclocondensation of 3-(o-Allylphenyl)pentane-1,5-dione: Synthesis of Tetracyclic Benzofused Azahomoisotwistane”

§  Chang, M.-Y.*; Lin, C.-H.; Chen, Y.-L.; Chang, C.-Y.; Hsu, R.-T. Org. Lett. 2010, 12, 1176-1179. “BF₃-Promoted Synthesis of Diarylhexahydrobenzo[f]isoquinoline”