Professor  Yeh-Long Chen


陳義龍      

Lab: Medicinal Synthesis Laboratory N844

Tel: 886-7-3121101 ext. 2684

Fax: 886-7-3125339

E-mail: yeloch@kmu.edu.tw

Education and Experience:

  • B.S. in Chemistry, Soochow University, Taipei, Taiwan (1983.9 – 1987.6)

  • M.S. in Medicinal Chemistry, Kaohsiung Medical College, Kaohsiung, Taiwan (1987.9 – 1989.6)

  • Ph.D. in Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan (1995.9 – 1999.6)

  • Instructor, School of Chemistry, Kaohsiung Medical University (KMU) (1991.7 – 1998.7)

  • Assistant Professor, School of Chemistry, KMU (1998.8 – 2002.7)

  • Associate Professor, Faculty of Medicinal and Applied Chemistry, KMU (2002.8 – 2005.7)

  • Professor, Department of Medicinal and Applied Chemistry, KMU (2005.8 – )

  • Director, Division of University Affairs Development, Office of Institutional Development, KMU (2006.8 – 2008.7)

  • Director, Department of Medicinal and Applied Chemistry, KMU (2008.8 – )

 

Research Interests:

  • Design, synthesis and evaluation of anticancer chemotherapeutic agents for the site-specific activation in tumor tissues

  • Design and synthesis of novel heterocyclic or metal-chelator bearing molecules as antimycobacterial agents

 

Teaching Course:

  • Organic Chemistry (Department of Biomedical Science & Environmental Biology and Department of Biotechnology)

  • Special Topic of Organic Chemistry (Department of Medical & Applied Chemistry Master’s program)

  • Special Topic of Organic Spectroscopy (Department of Medical & Applied Chemistry Master’s program)

 

Selected Publications:

  1. Tseng CH, Chen YL, Lu PJ, Yang CN, Tzeng CC (2008) “Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives” Bioorg. & Med. Chem. 15, 3151-3162.

  2. Chen YL, Lin HC, Yang CN, Lu PJ, Tzeng CC (2008) “Synthesis and antiproliferative evaluation of certain 4-anilino-7-methoxyfuro[2,3-b]quinoline and 4-anilino-6-methoxyfuro[2,3-b]quinoline derivatives. Part 5” Chem. & Biodiv. 4, 267-278.

  3. Lin MW, Tsao LT, Chang LC, Chen YL, Huang LJ, Kuo SC, Tzeng CC, Lee MR, Wang JP (2007) “Inhibition of lipopolysaccharide-stimulated NO production by a novel synthetic compound CYL-4d in RAW 264.7 macrophages involving the blockade of MEK4/JNK/AP-1 pathway” Biochem. Pharmacol. 73, 1796-1806.

  4. Chen YL, Zhao YL, Lu CM, Tzeng CC, Wang JP (2006). “Synthesis, Cytotoxicity, and Anti-inflammatory Evaluation of 2-(Furan-2-yl)-4-(phenoxy)quinoline Derivatives. Part 4” Bioorg. & Med. Chem. 14, 4373-4378.

  5. Chen YL, Huang CJ, Huang ZY, Tseng CH, Chang FS, Yang SH, Lin SR, Tzeng CC (2006). “Synthesis and Antiproliferative Evaluation of Certain 4-Anilino-8-methoxy-2-phenylquinoline and 4-Anilino-8-hydroxy-2-phenyl­quinoline Derivatives” Bioorg. & Med. Chem. 14, 3098-3015.

  6. Chen YL*, Huang HY, Chen YW, Huang ZY, Tzeng CC, Liu CL, Yao CW (2005). “Synthesis and Antimycobacterial Evaluation of Metal-chelator Bearing Fluoroquinolones” Chin. Pharm. J. 57, 57-70.

  7. Chen YL, Chen IL, Wang TC, Han CH, Tzeng CC (2005). “Synthesis and Anticancer Evaluation of Certain 4-Anilinofuro[2,3-b]quinoline and 4-Anilinofuro[3,2-c]quinoline Derivatives” Eur. J. Med. Chem. 40, 928-934.

  8. Wang TC, Chen IL, Lu PJ, Wong CH, Liao CH, Tsiao KC, Chang KM, Chen YL, Tzeng CC (2005). “Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime- containing flavone and isoflavone derivatives” Bioorg. & Med. Chem. 13, 6045-6053.

  9. Chen YL*, Lu CM, Lee SJ, Kuo DH, Chen IL, Wang TC, Tzeng CC (2005). “Synthesis, Antiproliferative, and Vasorelaxing Evaluations of Coumarin a-Methylidene-g-butrolactones” Bioorg. & Med. Chem. 13, 5710-5716.

  10. Zhao YL, Chen YL, Chang FS, Tzeng CC (2005). “Synthesis and cytotoxic evaluation of certain 4-anilino-2-phenylquinoline derivatives” Eur. J. Med. Chem. 40, 792-797.

  11. Huang YB, Wu PC, Hsu MW, Chen YL, Tzeng CC, Tsai YH (2005). “Highly Sensitive Analysis of The Anti-tumor Agent 1-[4-(furo[2,3-b]-quinolin-4-yl­amino)phenyl]ethanone in Rat Plasma by High-performance Liquid Chromatography Using Electrochemical Detection” J. Pharm. Biomed. Anal. 38, 551-555.

  12. Kuan YH, Lin RH, Tsao LT, Chen YL, Tzeng CC, Wang JP (2005). “Inhibition of Phospholipase D Activation by CYL-26z in Formyl Peptide-stimulated Neutrophils Involved the Blockade of RhoA Activation” Biochem. Pharmacol. 70, 901-910.

  13. Zhao YL, Chen YL, Sheu JY, Chen IL, Wang TC, Tzeng CC (2005) “Synthesis and Antimycobacterial Evaluation of Certain Fluoroquinolone Derivatives” Bioorg. & Med. Chem. 13, 3921-3926.

  14. Wu PC, Huang YB, Chang CK, Chen YL, Tzeng CC, Tsai YH (2005). “Pharmacokinetics of A New Antitumor Agent, 1-[3-(Furo[3,2-c]quinolin-4-ylamino)phenyl]ethanone-O-methyloxime, in Rat Using A High Performance Liquid Chromatography Method” J. Food & Drug Analysis, 13, 38-42.

  15. Zhao YL, Chen YL, Tzeng CC, Chen IL, Wang TC, Han CH (2005). “Synthesis and Cytotoxic Evaluation of Certain 4-Anilinofuro[2,3-b]quinoline and 4-Anilino-2-furanylquinoline Derivatives” Chem. & Biodiv. 2, 205-214.

  16. Chen YL*, Hung, HM, Lu CM, Li KC, Tzeng CC (2004).“Synthesis and Anticancer Evaluation of Certain Indolo[2,3-b]quinoline Derivatives”Bioorg. & Med. Chem. 12, 6539-6546. (NSC 93-2320-B-037-051)

  17. Hsu SL, Chen YL, Tzeng CC (2004).“Synthesis and Cytotoxic Evaluation of Certain Tricyclic Benzo[g]quinolin-4(1H)-one and Benzo[g]- quinolin-4,9,10-trione Derivatives Heterocycles, 63, 529-537.

  18. Chen YL*, Chen IL, Lu CM, Tzeng CC, Tsao LT, Wang JP (2004).“Synthesis and Anti-inflammatory Evaluation of 4-Anilinofuro[2,3-b]quinoline and 4-Phenoxyfuro[2,3-b]quinoline Derivatives. Part 3”Bioorg. & Med. Chem. 12, 387-392. (NSC 91-2113-M-037-013)

  19. Chen YL, Sheu JY, Tzeng CC (2003).“Drug Development for the Treatment of Tuberculosis (TB) Infections”Chemistry (The Chinese Chem. Soc., Taipei) 61, 599-609.

  20. Chen YL*, Chen IL, Lu CM, Tzeng CC, Tsao LT, Wang JP (2003).“Synthesis and Anti-inflammatory Evaluation of 9-Phenoxyacridine and 9-Phenoxyfuro[2,3-b]quinoline Derivatives. Part 2”Bioorg. & Med. Chem. 11, 3921-3927.

  21. Chen YL*, Chen PH, Chung CH, Li KC, Jeng HY, Tzeng CC (2003).“Synthesis and Cytotoxicity Evaluation of Metal-chelator Bearing Flavone, Carbazole, Dibenzofuran, Xanthone, and Anthraquinone”Helv. Chim. Acta, 86, 778-786. (NSC 90-2113-M-037-014)

Patent:

  1. Chen YL (2006). “Novel 4-Anilinofuro[3,2-c]quinoline Derivatives, and Preparation Processes and Uses of The Same” ROC Patent No. , Int. Cl.: C07D-491/0480; A61K-031/4355.

  2. Tzeng CC, Chen YL, Ko FN (2004). “6-Fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic Acid Derivatives, Their Preparation and Pharmaceutical Compositions” ROC Patent No. 00584632, Int. Cl.: C07D-401/10; A61K-031/495.

  3. Chen YL (2003). “4-Anilinofuro[3,2-c]quinoline Derivatives, and Preparation Processes and Uses of The Same” United States Patent No. 6656949.

  4. Tzeng CC, Chen YL, Ko FN (2002). “6-Fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4­oxoquinoline-3-carboxylic Acid Derivatives, Their Preparation and Pharmaceutical Compositions” United States Patent No. 6492373.

  5. Tzeng CC, Lee KH, Chen YL, Huang BR (1999). “Antineoplastic a-Mehtylene-g-butyrolactones” United States Patent No. 5962460 A 19991005 CAN 131:243173 AN 1999:633298 CAPLUS.

  6. Tzeng CC, Chen YL, and Teng CM (1997). “Antiplatelet Coumarin Derivatives” ROC Patent No. 00293819, Int. Cl.: C07D-311/08; A61K-031/35. (NSC 83-0412-B-037-011)

  7. Tzeng CC, Chen YL, Wang TC, and Teng CM (1997). “Proparation of a-Mehtylene-g-butyrolactones As New Inhibitors of Platelet Aggregation” United States Patent No. 5646164 A 19970708 CAN 127:161700 AN 1997: 456149 CAPLUS. (NSC 83-0412-B-037-011)

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