Associate Professor Tzu-Pin Wang


王子斌

Tzu-Pin Wang, Ph.D.

Office: N818 (behind Rm N845)                                                           

Laboratory: N845, Nucleic Acid Chemistry Laboratory

Phone: 07-3121101 ext.2756

E-mail: tzupinw@kmu.edu.tw

Education

  1. National Taiwan University, B.S. in Forestry)。
  2. California State University, Fullerton; CSUF; M.S. in Biochemistry)。
  3. State University of New York, College of Environmental Science and Forestry; SUNY-ESF; Ph.D. in Chemistry (2000.12)

Research Highlights

  1. Chemistry of ribozymes and aptamers: in vitro evolution and selection of novel ribozymes and aptamers; structure determination of ribozymes and aptamers; determination of catalytical mechanisms of ribozymes.
  2. Nucleic acid chemistry and applications: phosphoramidation chemistry for post-synthetic modifications and conjugations of DNA/RNA; novel and effective bioorthogonal chemical approaches for nucleic acid modifications and labeling; novel approaches for synthesis of peptide-oligonucleotide conjugates (POCs); synthesis of POCs for achieving gene silencing and RNA interference ; novel methods for universal labeling and modifications DNA/RNA; phosphoramidation reactions for DNA microarray fabrication and detection; novel ribozymes and aptamers for developments of nucleic acid-based biosensors.
  3. Agarose Chemistry: purification of biotechnological grade agarose from indigenous Rhodophyta in Taiwan; synthesis of agarose derivatives useful in biotechnology and bioengineering.

Experience

  1. Kaohsiung Medical University, associate professor (2013.02-now).
  2. Kaohsiung Medical University, assistant professor (
  3. SUNY, University at Buffalo, Department of Chemistry, postdoctoral research associate.
  4. SUNY, University at Buffalo, Department of Chemistry, postdoctoral research associate.
  5. SUNY-ESF, Department of Chemistry, teaching and research assistants.
  6. CSUF, Department of Chemistry and Biochemistry, teaching and research assistants.

Patents:

Wang, T.-P. and Y.-J. Chiou (2014) Methods for conjugating nucleic acids with small molecules, U.S. Patent No.: US 8,765,934 B2, Date of Patent: Jul. 1, 2014.

Wang, T.-P. and Y.-J. Chiou (2014)將核酸街上小分子的方法(Methods for conjugating nucleic acids with small molecules), Taiwan Patent No.: I464402, Date of Patent: Dec. 11, 2014.

Journal Publications in the Past Ten Years:

Su, Y.-C., Y.-L. Lo, C.-C. Hwang, L.-F. Wang, M. H. Wu, E.-C. Wang, Y.-M. Wang, T.-P. Wang*. (2014) Azide–alkyne cycloaddition for universal post-synthetic modifications of nucleic acids and effective synthesis of bioactive nucleic acid conjugates. Org. Biomol. Chem.,12, 6624–6633. (SCI)

Su, Y.-C., H.-Y. Chen, N. C. Ko, C.-C. Hwang, M. H. Wu, L.-F. Wang, Y.-M. Wang, S.-N. Chang, E.-C. Wang*, T.-P. Wang*. (2014) Effective and site-specific phosphoramidation reaction for universally labeling nucleic acids. Anal. Biochem., 449, 118-128. (SCI)

Chang, Y.-T., C.-Y. Lin, P.-L. Lu, C.-C. Lai, T.-C. Chen, C.-Y. Chen, D.-C. W, T.-P. Wang, C.-M. Lin, W.-R. Lin*, Y.-H. Chen. (2014) Stenotrophomonas maltophilia bloodstream infection: Comparison between community-onset and hospital-acquired infections. J. Microbiol. Immunol. Infect., 47, 28-35. (SCI)

Huang, S.-J., T.-P. Wang, S.-I. Lue, L.-F. Wang*. (2013) Pentablock copolymers of pluronic F127 and modified poly(2-dimethyl amino)ethyl methacrylate for internalization mechanism and gene transfection studies.Int. J. Nanomedicine, 8, 2011–2027. (SCI)

Hwang, C.-C.*, Y.-H. Chang, H.-J. Lee, T.-P. Wang, Y.-M. Su, H.-W. Chen, P.-

H. Liang. (2013) The Catalytic Roles of P185 and T188 and Substrate-Binding Loop Flexibility in 3a-Hydroxysteroid Dehydrogenase/Carbonyl Reductase from Comamonas testosterone. PLOS ONE. 8, e63594. (SCI)

Wu, S.-C.,K.-L. Lin,T.-P. Wang,S.-C. Tzou,G. Singh,M.-H. Chen,T.-L. Cheng,C.-Y. Chen,G.-C. Liu,T.-W. Lee,S.-H. Hu, and Y.-M. Wang*. (2013) Imaging specificity of MR-optical imaging agents following the masking of surface charge by poly(ethylene glycol). Biomaterials, 34, 4118-4127. (SCI)

Hsu, S. C. N., T.-P. Wang, C.-L. Kao, H.-F. Chen, P.-Y. Yang, and H.-Y. Chen*. (2013) Theoretical study on the protonation of the one-electron reduced guanine-cytosine base pair by water. J. Phys. Chem. B, 117, 2096−2105. (SCI)

Chen, P.-Y., C.-Y. Zhou, H.-M. Chen, C.-H. Yang, T.-P. Wang*, and E.-C. Wang*. (2013) Synthesis of novel four-fused-ring chromeno-benzoxepinones from salicylaldehydes and 1-benzoxepin-5-ones via the oxa-Michael reaction/aldol condensation.ARKIVOC, (iii) 24-35. (SCI)

Chen, P.-Y., Y.-H. Wu, M.-H. Hsu, T.-P. Wang, E.-C. Wang*. (2013) Cerium ammonium nitrate-mediated the oxidative dimerization of p-alkenylphenols: a new synthesis of substituted (±)-trans-dihydrobenzofurans. Tetrahedron, 69. 653-657. (SCI)

Wang, T.-P.*, N. C. Ko, Y.-C. Su, E.-C. Wang, S. Severance, C.-C. Hwang, Y. T. Shih, M. H. Wu and Y.-H. Chen*. (2012) Advanced aqueous-phase phosphoramidation reactions for effectively synthesizing peptide-oligonucleotide conjugates trafficked into a human cell line. Bioconjugate Chem., 23, 2417-2433. (SCI)

Chen,S.-H.,Y.-T. Kuo,G. Singh, T.-L. Cheng,Y.-Z. Su,T.-P. Wang,

  1. . (2012) Development of a Gd(III) Based Receptor-Induced Magnetization Enhancement (RIME) Contrast Agent for b-Glucuronidase Activity Profiling. Inorg. Chem., 51, 12426-12435.

Chen, P.-Y., K.-S. Huang, C.-C. Tsai, T.-P. Wang, and E.-C. Wang*. (2012) Pd(II)-Mediated Cyclization of o-Allylbenzaldehydes in Water: A Novel Synthesis of Isocoumarins. Org. Lett., 14, 4930-4933. (SCI)

Chen, P.-Y., H.-M. Chen, M. Y. Chiang, Y.-F. Wang, S-R. Li, T.-P. Wang,E.-C. Wang*. (2012) A novel and chemoselective synthesis of substituted 3,4-dihydroisoquinolin-1(2H)-ones from o-oxiranylmethylbenzonitrile intermediates and TBAB/NaCN. Tetrahedron, 68, 3030-3036. (SCI)

Wang, T.-P.*, L.-L. Chang,S.-N. Chang,E.-C. Wang, L.-C. Hwang, Y.-H. Chen, and Y.-M. Wang (2012)Successful Preparation and Characterization of Biotechnological Grade Agarose from Indigenous Gelidium amansii of Taiwan. Process Biochem., 47, 550–554. (SCI)

Wang, T.-P.*,Y.-C. Su,Y. Chen,Y.-M. Liou,K.-L. Lin,E.-C. Wang,L.-C. Hwang,Y.-M. Wang, and Y.-H. Chen (2012) In vitro Selection and Characterization of a Novel Zn(II)-Dependent Phosphorothiolate Thiolesterase Ribozyme. Biochemistry, 51, 496-510. (SCI)

Chen, B.-H.*, M.-H. Hung, J. Y.-F. Chen, H.-W. Chang, M.-L. Yu, L. Wan, F. J. Tsai, T.-P. Wang, T.-F. Fu, C.-C. Chiu (2012) Anti-allergic activity of grapeseed extract (GSE) on RBL-2H3 mast cells. Food Chem., 132, 968-974. (SCI)

Chen, P.-Y., T.-P. Wang, K.-S. Huang, C.-L. Kao, J.-C. Tsai, E.-C. Wang* (2011) tert-BuOK-mediated carbanioneyne intramolecular cyclization: synthesisof 2-substituted 3-benzylbenzofurans. Tetrahedron, 67, 9291-9297. (SCI)

Chen, P.-Y., T.-P. Wang, M. Y. Chiang, K.-S. Huang, C.-C. Tzeng,Y.-L. Chen, E.-C. Wang*. (2011) Environmentally benign syntheses of flavanones. Tetrahedron, 67, 4155-4160. (SCI)

Chen, L.-Y., S.-R. Li, P.-Y. Chen, H.-C. Chang, T.-P. Wang, I.-L. Tsai, and E.-C. Wang*. (2010) 2,3-Dichloro-5,6-dicyanobenzoquinone (DDQ) mediated oxidation-dehydrogenation of 2-aroyl-3,4-dihydro-2H-benzopyrans : synthesis of 2-aroylbenzopyran-4-ones.ARKIVO, xi, 64-76. (SCI)

Hwang, L.-C.*, Y.-C. Su,T.-P. Wang,L.-T. Liu,and G.-H. Lee (2010)Crystal structure of 3-amino-2-benzyl-6-bromo-1,2,4-triazin-5(2H)-one. X-ray Struct. Anal. Online,26, 61-62.

Ko, C.-H.*, Z.-P. Lin, J. Tu, C.-H. Tsai, C.-C. Liu, H.-T. Chen, T.-P. Wang (2010) Xylanase production by Paenibacillus campinasensis BL11 and its pretreatment of hardwood kraft pulp bleaching.  Int. Biodeterior. Biodegradation., 64, 13–19. (SCI)

Su, S.-H., W.-C. Tsai, C.-Y. Lin, W.-R. Lin, T.-C. Chen, P.-L. Lu, P.-M. Huang, J.-R. Tsai, Y.-L. Wang, M.-C. Feng, T.-P. Wang, Y.-H. Chen (2010) Clinical features and outcomes of spinal tuberculosis in southern Taiwan. J. Microbiol. Immunol. Infect., 43, 291–300. (SCI)

Wang, T.-P.*, Y.-J. Chiou, Y. Chen, E.-C. Wang, L.-C. Hwang, B.-H. Chen, Y.-H. Chen, and C.-H. Ko (2010) Versatile phosphoramidation reactions for nucleic acid conjugations with peptides, proteins, chromophores, and biotin derivatives.Bioconjugate Chem. 21, 1642–1655. (SCI)

Chen, L.-Y., S.-R. Li, P.-Y. Chen, I.-L. Tsai, C.-L. Hsu, H.-P. Lin, T.-P. Wang, E.-C.Wang* (2009)  A novel carbanion-olefin intramolecular cyclization: synthesis of substituted 2-aroyl-3,4-dihydro-2H-benzopyrans from salicylaldehydes. Tetrahedron Lett., 50, 5748-5750. (SCI)

Quintanar, L.,C. Stoj, T.-P. Wang, D. J. Kosman,* and E. I. Solomon* (2005) Role of Aspartate 94 in the Decay of the Peroxide Intermediate in the Multicopper Oxidase Fet3p. Biochemistry, 44, 6081-6091. (SCI)

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