Professor Eng-Chi Wang

Lab: Organic Synthetic Chemistry Laboratory (N843)

Tel: 886-7-3121101 ext. 2221

Fax: 886-7-3125339

E-mail:enchwa@kmu.edu.tw

Education and Experience:

• B.S., Pharmacy, Kaohsiung Medical university, Taiwan (1969-1973)

• M.S., Pharmaceutical Sciences, Kaohsiung Medical university, Taiwan (1982-1985)

• PhD., Pharmaceutical Sciences, Kaohsiung Medical university, Taiwan ( 1989-1994 )

• Research fellow, Division of Synthetic Chemistry, College of Pharmacy, Toyama Pharmaceutical and Medical University, (1986-1987 ) Japan

• Assistant (1974-1978), Lecturer (1978-1984), and Associate professor (1984-1991), Faculty of Pharmacy, Kaohsiung Medical University, Taiwan

• Associate Professor (1991), Professor ( 1999- ), Faculty of Medicinal & Applied Chemistry, Kaohsiung Medical university

• Director (2000-2006), Faculty of Medicinal & Applied chemistry, Kaohsiung Medical university

• Member of Board of Trustee (2000- ), Ta-Jen University of Technology, Pi-Tung, Taiwan

Research Interests:

• Synthetic organic chemistry on benzocarbocyclic and benzoheterocyclic compounds.

• New methodologies for functional group interchange

• Searching potential anti-viral, and anti-cancer compounds.

Selected Publications:

1. Wang, E.-C.; Li, S.-R.  “ Intermediate compounds and processes for the preparation of 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran”.U.S. Pat. Appl. Publ.  (2010), 6pp.  CODEN: USXXCO US 2010298582 A1 20101125 AN 2010:1465099.
2. Wang, Eng-Chi; Li, Sie-Rong. “Processes for preparing isoflavonoids using 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran as a starting material”. U.S. Pat. Appl. Publ.  (2010), 11pp.  CODEN: USXXCO US 2010298581 A1 20101125 AN 2010:1465096.
3. Chen, L.-Y.; Li, S.-R.; Chen, P.-Y.; Chang, H.-C.; Wang, T.-P.; Tsai, I.-L.; Wang, E.-C.*  ARKIVOC (Gainesville, FL, United States)  2010, 11,  64-76.
4. Wang, T.-P.; Chiou, Y.-J.; Chen, Y.; Wang, E.-C.; Hwang, L.-C.; Chen, B.-H.; Chen, Y.-H.; Ko, C.-H. Bioconjugate Chem. 2010, 21, 1642-1655.
5. Tsai, J.-C.; Li, S-R.; Chiang, Michael Y.; Chen, L.-Y.; Chen, P. Y.; Lo, Y.-F.; Wang, C.-H.; Lin, C.-N. Wang, E.-C.* “A novel synthesis of 3-alkoxymethylcoumarins from 3-cyanochromenes via 2-phenylimino-3-alkoxymethylchromenes intermediates” J. Org. Chem. 2009, 74, 8789-8801.
6. Li, S-R.; Shu, C.-J.; Chen, L.-Y.; Chen, H.-M.; Chen, P. Y.;Wang, E.-C.^* “Synthesis of substituted 2-aroyl-3-methylchromen-4-ones from isovanillin via 2-aroyl-3- methylchroman intermediates” Tetrahedron 2009, 65, 8702-8707.
7. Chen, L.-Y.; Li, S-R.; Chen, P. Y.; Tsai, I.-L.; Hsu, C. L.; Lin, H. P.; Wang, T. P.;Wang, E.-C.* “A novel carbanion-olefin intramolecular cyclization: synthesis of substituted 2-aroyl-1-dihydrobenzopyrans from salicylaldehydes” Tetrahedron Lett.2009, 50, 5748-575
8. Li, S-R.; Chen, P. Y.; Chen, P. Y.; Lo, Y.-F.; Tsai, I.-L.; Wang, E.-C.* “Synthesis of haginin E, equol, daidzein, and formononetin from resorcinolvia isoflavene intermediates” Tetrahedron Lett. 2009, 50, 2121-2123.
9. Lin, Y. S.; Huang, K. S.;* Yang, C. H.;*Wang, E.-C.* Jhong, J. Y.; Hsu, C. J.; Kuo, C. Y. “Precise control of chitosan microparticles using a double T-junction microchannel chip: facile separation of satellite drops” LAB CHIP, 2009, 9, 145-150.
10. Tsai, J.-C.; Li, S-R.; Chen, L.-Y.; Chen, P. Y.; Jhong, J. Y.; Shu, C.-J.; Lo, Y.-F.; Lin, C.-N. Wang, E.-C.* “Synthesis of 3-aryl-2,5-dihydro-1-benzoxepines from Phenol via ring-closing metathesis” J. Chin. Chem. Soc. 2008, 55, 1317-1321.
11. Tsai, J.-C.; Li, S-R.; Chen, L.-Y.; Chen, P. Y.;  Hsu, Sodio C.-N.; Lin, C.-N.; Wang, E.-C..* “Synthesis of substituted 2,5-dihydro-1-naphthoxepines from 1-naphthol via ring-closing metathesis” ARKIVOC (Gainesville, FL, United States) 2008, 12, 205-217.
12. Lin, G.-T.; Tseng, H.-F.; Chang, C.-K.; Chuang, L.-Y.; Liu, C.-S.; Yang, C.-H.; Tu, C.-J.; Wang, E.-C.; Tan, H.-F.; Chang, C.-C.; Wen, C.-H.; Chen, H.-C.; Chang, H.-W.  “SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women”. Chin. J. Physiol. 2008, 51, 32-41.
13. Li, S-R.; Chen, H.-M.; Chen, P. Y.;  Tsai, J.-C.; Chen, L.-Y.; Wang, E.-C.;* Huang, Y.-T.; Wei, Y.-C.; Lu, P.-J.. “Synthesis and evaluation of the cytotoxicities of neoflavenes.” J. Chin. Chem. Soc. 2008, 55, 923-932.
14. Li, S-R.; Chen, H.-M.; Chen, L.-Y.; Tsai, J.-C.; Chen, P. Y.; Hsu, Sodio C.-N.; Wang, E.-C..* “Synthesis of 1-benzoxepin-5-ones (ols) from salicylaldehydes via ring-closing metathesis” ARKIVOC (Gainesville, FL, United States) 2008, 2, 172-182.
15. Li, S-R.; Chen, L.-Y.; Tsai, J.-C.; Tzeng, J. Y.; Tsai, I. L.; Wang, E.-C.* “New syntheses of dalbergichromene and dalbergin from vanillin via neoflavene intermediate.” Tetrahedron Lett. 2007, 48, 2139-2141.
16. Wang, E.-C.; Wu, C. H. ; Chien, S. C. ; Chiang, W. C.;  Kuo, Y. H.* “An efficient and chemoselective deprotection of aryl- and styrenyldithioketals (acetals).” Tetrahedron Lett. 2007, 48, 7706-7708.
17. Li, S-R.; Chen, L.-Y.; Tsai, J.-C.; Tzeng, J. Y.; Tsai, I. L.; Wang, E.-C.* “New syntheses of dalbergichromene and dalbergin from vanillin via neoflavene intermediate.” Tetrahedron Lett. 2007, 48, 2139-2141.
18. Chen, P. Y.; Chen, H. M.; Chen, L. Y.; Tzeng, J. Y.;  Tsai, J. C.; Chi, P. C.; Li, S. R.;  Wang, E. C. * “Claisen rearrangement/Baylis-Hillman reaction/ring-closing metathesis as bases for the construction of substituted cyanonaphthalenes.” Tetrahedron 2007, 63, 2824-2828.
19. Wang, E. C.; Wein, Y. S.; Kuo, Y. H.*, “A concise and efficient Synthesis of Salvinal from Isoeugenal via a Phenoxenium ion Intermediate”Tetrahedron Lett. 2006, 47, 9195-9197.
20. Hou, D. R.*; Cheng, H. Y.; Wang, E. C. “Efficient Synthesis of Oncinotine and Neooncinotine” J. Org. Chem. 2004, 69, 6094-6099.
21. Tsai, T. W. ; Wang, E. C.*; Li, S. R.;  Chen, H. M.; Lin, Y. L.;  Wang, Y. F.; Huang, K.S. “A New Synthesis of Benzofurans from Phenols viaClaisen Rearrangement and Ring-Closing Metathesis ”J. Chin. Chem. Soc. 2004, 51(6), 1307-1318.
22. Tsai, T. W.; Wang, E. C.* “A new synthesis of angelicin from 7-hydroxycoumarin via C-propenation-O-vinylation and ring-closing metathesis” J. Chin. Chem. Soc. 2004, 51(5), 1019-1024.
23. Wang, E. C.*;Huang, K. S.; Chen, H. M.; Wu, C. C.;  Lin, G. J.  “An efficient method for the preparation of nitriles via the dehydration of aldoximes with phthalic anhydride”J. Chin. Chem. Soc. 2004, 51 (3), 619-627.
24. Hou, D. R.*; Cheng, H. Y.; Wang, E. C. “Efficient Synthesis of Oncinotine and Neooncinotine” J. Org. Chem. 2004, 69, 6094-6099.
25. Huang, K. S.; Wang, E. C.*“Synthesis of Substituted Indenes from Isovanillin via Claisen Rearrangement and RCM” J. Chin. Chem. Soc. 2004,51, 383-391.
26. Huang, K. S.; Wang, E. C.*; Chen, H. M.  “Synthesis of 4-Alkoxy-3-methoxy - 5H- benzocycloheptenes and 2-Alkoxy-3-methoxy-5H-benzocycloheptenes”J. Chin, Chem. Soc. 2004, 51, 807-816.
27. Tsai, T. W.; Wang, E. C.*;Huang, K. S.; Li, S. R. ; Wang , Y. F. ; Lin, Y. L. ; Chen, Y. H. “Synthesis of Benzofurans from Isovanillin via C-propenylation-O-vinylation and Ring-closing metathesis” Heterocycles
28. Huang, K. S.; Wang, E. C.*; Chen, H. M.  “Synthesis of Naphthalenes and   Naphthols” J. Chin. Chem. Soc. 2004, 51, 585-605.
29. Wang, E. C.*; Chen, H. F. ; Feng, P. K. ; Lin, Y. L.; Hsu, M. K. “A New Synthesis of 3-Alkyl-1-Isoindolinones” Tetrahedron Lett. 2002, 43(50), 9163-9165.
30. Huang, K. S.;Wang, E. C.* “A Novel Synthesis of Substituted Naphthalenes via Claisen Rearrangement and RCM Reaction” Tetrahedron Lett.2001, 42, 6155-6157.