Professor Li-Fang Wang

Lab: N834, First Teaching Building

TEL: +886-7-3121101 ext. 2217

Fax: +886-7-3125339

E-mail: lfwang@kmu.edu.tw

Education:

• B.S. Department of Chemistry, National Tsing Hwa University 1983

• M.S. Department of Chemical Engineering, National Tsing Hwa University 1985

• Ph.D. Department of Polymer Science, Polytechnic University, USA 1990

Research interests:

• Synthesis and characterization of biomaterials

• Multifunctional nanoparticulate preparation

• Controlled drug delivery

Selected publications:

1.           L. F. Wang*, and J. M. Wang, 2002, “Insolubilization of sodium chondroitin sulfate by forming a semi-interpenetrating polymer network with acrylic acid: A potential carrier for colon-specific drug delivery” J. Appl. Polym. Sci., 85 (1), pp 114 – 128. (SCI) NSC-89-2216-E037-001

2.           L. F. Wang* and H. N. Chiang, 2002, “Kinetics and hydrolysis of polymeric prodrug containing ibuprofen, ketoprofen and naproxen as pendent agents” J Biomaterial Sci: Polym. Edn., 13 (3), pp 287 – 299. (SCI) NSC-87-2216-E037-001

3.           C. C. Chen, L. F. Wang*, J. J. Wang, T. C. Hsu* and C. F. Chen, 2002, “Diacid architecture effect on the synthesis and microstructure of rigid-rod poly(benzobisimidazoles)”, J. Mater. Sci., 37, pp 4109 - 4115. (SCI) 89-CPC-7-110-001

4.           L. F. Wang*, J. M. Wang and W. B. Chen, 2002, “Synthesis and Properties of a polymeric prodrug containing naproxen as a pendent group” J. Pharm. Pharmacol., 54, pp 1129 – 1135. (SCI) NSC-88-2216-E037-001

5.           L. F. Wang*, W. B. Chen, T. Y. Chen and S. C. Lu, 2003, “Hydroxypropyl methyl-cellulose/ polyacrylic acid blend films for drug release”, J Biomaterial Sci:. Polym. Edn., 14(1),pp 27-44. (SCI) NSC-89-2815-C037-002B

6.           L.F. Wang*, S. S. Shen and S. C. Lu, 2003, “Synthesis and characterization of chondroitin sulfate-methacrylate hydrogels”, Carbohydrate Polymer, 52 (4), 389 – 396. (SCI) NSC-90-2216-E037-001

7.           L.F. Wang, C.C. Ou, K. Striebel, and J. S. Chen, 2003, “ Study of Mn Dissolution from LiMn2O4 Spinel Electrodes Using Rotating Ring-Disk Collection Experiments”, J Electro. Chem., 150(7), pp A905－A911. (SCI)

8.           L. F. Wang*, W. B. Chen, J. S. Chen and S. Y. Fan, 2005, “Characterization of polyelectrolyte complexes between chondroitin sulfate and chitosan in solid state” J Biomed Mater Res, 75A(10), 128-137. (SCI) NSC-91-2216-E037-001

9.           M..F. Tsai, Y.L. Chiang, and L. F. Wang*, 2005, “Oral sustained delivery of diclofenac sodium using calsium chondroition sulfate matrix” J Biomaterial Sci:. Polym. Edn. 16(10), 1319-1331. (SCI) NSC-91-2216-E037-001

10.       L.F. Wang, B.J. Fang, and J.S. Chen, 2005, “Rotating ring-disc electrode measurements of manganese dissolution and capacity loss of Li1+xMn2-xO4 and Li1+xAlyMn2-x-yO4 spinel electrodes for lithium-ion batteries” J Power Sources, 150(9), 1-10 (SCI).

11.       C.F. Chen, L.J. Juang, T.C. Hsu*, J.J. Wang, L.F. Wang, 2006, “Diacid architecture effect on the synthesis and microstructure of rigid-rod poly(benzobisthiazoles)” Polymer International, 55 (12), 1450-1455. (SCI)

12.       J.S. Chen∗, L.F. Wang∗, B.J. Fang , S.Y. Lee, R.Z. Guo, 2006, “Rotating ring–disk electrode measurements on Mn dissolution and capacity losses of spinel electrodes in various organic electrolytes” J Power Sources, 157(1), 515-521 (SCI)

13.       L.F. Wang, B.J. Fang, Y.K. Lin, J.S. Chen*, 2006, “Investigation of silica additive for high-rate sealed lead-acid cells” Electrochimica Acta, 51 (20), 4135-4141 (SCI)

14.       Y.S. Peng, S.C. Lin, S.J. Huang, Y.M. Wang, and L.F. Wang*, 2006, “Chondroitin sulfate-based anti-inflammatory macromolecular prodrugs” Eur. J. Pharm. Sci. 29(09), 60-69 (SCI) NSC-92-2216-E037-001

15.       J.M. Wang, S.C. Tseng, and L.F. Wang*, 2007, “Controlled immobilization of chondroitin sulfate in polyacrylic acid networks” J Biomaterial Sci:. Polym. Edn. 18 (1), 17-34. (SCI) NSC-93-2216-E037-001

16.       S.C. Wang, B.H. Chen, L.F. Wang*, and J.S. Chen, 2007, “Characterization of chondroitin sulfate and its interpenetrating polymer network hydrogels for drug -sustained release” International Journal of Pharmaceutics 329(1), 103-109. NSC-94-2216-E037-001.

17.       M.F. Tsai, H.Y. Tsai, Y.S. Peng, L.F. Wang, J.S. Chen, and S.C. Lu, 2007, “Characterization of hydrogels prepared from copolymerization of different degrees of methacrylate-grafted chondroitin sulfate macromers and acrylic acid” J Biomed Mater Res: Part A (04/04/2007, Accepted) NSC-94-2216-E037-001

18.       Y.L. Lou, Y.S. Peng, B.H. Chen, L.F. Wang*, and K.W. Leong, “Poly(ethylene imine)-g-Chitosan Using EX-810 as a Spacer for Non-viral Gene Delivery Vectors” J Biomed Mater Res: Part A , Accepted on 11/27/2007 (SCI, Mater Sci-Biomaterial)

19.       J.S. Chen^∗, L.F. Wang^∗, B.J. Fang , S.Y. Lee, R.Z. Guo, 2006, “Rotating ring–disk electrode measurements on Mn dissolution and capacity losses of spinel electrodes in various organic electrolytes” J Power Sources, 157(1), 515-521 (SCI, IF=3.792, 7/70)

20.       L.F. Wang, B.J. Fang, Y.K. Lin, J.S. Chen*, 2006, “Investigation of silica additive for high-rate sealed lead-acid cells” Electrochimica Acta, 51 (20), 4135-4141 (SCI, IF=3.325, 4/24)

21.       Y.S. Peng, S.C. Lin, S.J. Huang, Y.M. Wang, and L.F. Wang*, 2006, “Chondroitin sulfate-based anti-inflammatory macromolecular prodrugs” Eur. J. Pharm. Sci. 29(09), 60-69 (SCI, IF= 2.608, 100/236)

22.       J.M. Wang, S.C. Tseng, and L.F. Wang*, 2007, “Controlled immobilization of chondroitin sulfate in polyacrylic acid networks” J Biomaterial Sci:. Polym. Edn. 18 (1), 17-34. (SCI, IF= 2.505, 16/76)

23.       S.C. Wang, B.H. Chen, L.F. Wang*, and J.S. Chen, 2007, “Characterization of chondroitin sulfate and its interpenetrating polymer network hydrogels for drug -sustained release” International Journal of Pharmaceutics, 329(1), 103-109. (SCI, IF=2.962, 78/216).

24.       M.F. Tsai, H.Y. Tsai, Y.S. Peng, L.F. Wang*, J.S. Chen, and S.C. Lu, 2008, “Characterization of hydrogels prepared from copolymerization of different degrees of methacrylate-grafted chondroitin sulfate macromers and acrylic acid” J Biomed Mater Res:, 84A (3), 727-739. (SCI, IF= 2.816, 14/59)

25.       A.L. Chen, H.C. Ni, L.F. Wang*, and J.S. Chen, 2008, “Biodegradable amphiphilic copolymers based on poly(ε-caprolactone)-graft chondroitin sulfate as drug carriers” Biomacromolecules, 9 (9), 2447-2457. (SCI, IF= 4.502, 6/76)

26.       Y.L. Lou, Y.S. Peng, B.H. Chen, L.F. Wang*, and K.W. Leong, 2009 “Poly(ethylene imine)-g-Chitosan Using EX-810 as a Spacer for Non-viral Gene Delivery Vectors” J Biomed Mater Res: Part A , 88A, 1058-1068. (SCI, IF= 2.816, 14/59)

27.       Shih-Jer Huang, Shuo-Li Sun, Tzu-Hua Feng, Kuo-Hsun Sung, Wen-Ling Lui, and Li-Fang Wang*, 2009 “Folate-Mediated Chondroitin Sulfate-Pluronic^® 127 Nanogels as a Drug Carrier” Eur. J. Pharm. Sci. 38, 64-73. (SCI, IF= 2.608, 100/236)

28.       Jia-Jyun Lin, Jenn-Shing Chen, Shih-Jer Huang, Jyun-Han Ko, Yu-Ming Wang, Ting-Lung Chen, and Li-Fang Wang*, 2009, ” Folic acid-Pluronic F127 magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications” Biomaterials 30, 5114-5124. (SCI, IF= 7.365, 1/19)

29.       Jyun-Han Ke, Jia-Jyun Lin, James, R Carey, Jenn-Shing Chen, Chiao-Yun Chen, and Li-Fang Wang*, 2010,”A Specific Tumor-Targeting Magnetofluorescent Nanoprobe for Dual-Modality Molecular Imaging”, Biomaterials 31, 1707-1715. (SCI, IF= 7.365, 1/19)

30.       Chien-Chih Chiu, Yin-Tzu Lin, Shuo-Li Sun, Kuo-Hsun Sung Li-Fang Wang*, and Jenn-Shing Chen, 2011, “Folate-mediated chondroitin sulfate/chitosan nanoparticulate polyelectrolyte complex as a drug carrier for doxorubicin delivery” J Biomaterial Sci:. Polym. Edn. (In press) (SCI, IF= 2.505, 16/76)

31.       Elsie Khai-Woon Toh, Hsing-Yin Chen, Yu-Lung Lo, Shih-Jer Huang, Li-Fang Wang*, 2011 “Succinated Chitosan as a Gene Carrier for Improved Chitosan Solubility and Gene Transfection” Nanomedicine: NBM (In press). (SCI, IF= 5.440, 11/59)

32.       Hun-Yu Tsai, Chien-Chih Chiu, Ping-Chih Lin, Su-Hwei Chen*, Shih-Jer Huang, and Li-Fang Wang*, 2011 “The Antitumor Efficacy of Released Doxorubicin from Crosslinked Nanoparticulate es” Macromol. Biosci. (In press) (SCI, IF= 3.108 13/76.)